Figure 1 | Cell Research

Figure 1

From: In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK)

Figure 1

Schematic diagrams of MK induction from human dermal fibroblasts. i) Direct conversion (iMK) method: three factors (p45MF-E2, Maf G, and Maf K) are required for direct conversion into iMK, which takes only 2 weeks3. ii) iPSC-mediated method: transient activation of c-Myc in iPSCs is required for efficient MK induction8. If megakaryocyte progenitor cells are immortalized (designated as MKCLs), MKCLs are valuable sources for MK production9. MK, megakaryocyte; iMK, induced megakaryocyte; iPSC, induced pluripotent stem cell; MKCL, megakaryocyte cell line.

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