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References
Bianco P . 'Mesenchymal' stem cells. Annu Rev Cell Dev Biol 2014; 30: 677–704.
Caplan AI, Correa D . The MSC: an injury drugstore. Cell Stem Cell 2011; 9: 11–15.
Barry F, Murphy M . Mesenchymal stem cells in joint disease and repair. Nat Rev Rheumatol 2013; 9: 584–594.
Delorme B, Nivet E, Gaillard J, Haupl T, Ringe J, Deveze A et al. The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties. Stem Cells Dev 2010; 19: 853–866.
Tome M, Lindsay SL, Riddell JS, Barnett SC . Identification of nonepithelial multipotent cells in the embryonic olfactory mucosa. Stem Cells 2009; 27: 2196–2208.
Nivet E, Vignes M, Girard SD, Pierrisnard C, Baril N, Deveze A et al. Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions. J Clin Invest 2011; 121: 2808–2820.
Rui K, Zhang Z, Tian J, Lin X, Wang X, Ma J et al. Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis. Cell Mol Immunol 2016; 13: 401–408.
Wang Y, Chen X, Cao W, Shi Y . Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol 2014; 15: 1009–1016.
Sun L, Wang D, Liang J, Zhang H, Feng X, Wang H et al. Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum 2010; 62: 2467–2475.
Wang D, Huang S, Yuan X, Liang J, Xu R, Yao G et al. The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus. Cell Mol Immunol 2017; 14: 423–431.
Bernardo ME, Fibbe WE . Mesenchymal stromal cells: sensors and switchers of inflammation. Cell Stem Cell 2013; 13: 392–402.
Krampera M, Cosmi L, Angeli R, Pasini A, Liotta F, Andreini A et al. Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 2006; 24: 386–398.
Burr SP, Dazzi F, Garden OA . Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance? Immunol Cell Biol 2013; 91: 12–18.
Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008; 2: 141–150.
Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X et al. Interleukin-17 enhances immunosuppression by mesenchymal stem cells. Cell Death Differ 2014; 21: 1758–1768.
Tian J, Rui K, Tang X, Wang W, Ma J, Tian X et al. IL-17 down-regulates the immunosuppressive capacity of olfactory ecto-mesenchymal stem cells in murine collagen-induced arthritis. Oncotarget 2016; 7: 42953–42962.
Yang R, Liu Y, Kelk P, Qu C, Akiyama K, Chen C et al. A subset of IL-17(+) mesenchymal stem cells possesses anti-Candida albicans effect. Cell Res 2013; 23: 107–121.
Alvaro-Gracia JM, Jover JA, Garcia-Vicuna R, Carreno L, Alonso A, Marsal S et al. Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial. Ann Rheum Dis 2017; 76: 196–202.
Goldstein BJ, Hare JM, Lieberman S, Casiano R . Adult human nasal mesenchymal stem cells have an unexpected broad anatomic distribution. Int Forum Allergy Rhinol 2013; 3: 550–555.
von Bahr L, Sundberg B, Lonnies L, Sander B, Karbach H, Hagglund H et al. Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy. Biol Blood Marrow Transplant 2012; 18: 557–564.
Hass R, Kasper C, Bohm S, Jacobs R . Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal 2011; 9: 12.
Galipeau J . The mesenchymal stromal cells dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road? Cytotherapy 2013; 15: 2–8.
Trounson A, McDonald C . Stem cell therapies in clinical trials: progress and challenges. Cell Stem Cell 2015; 17: 11–22.
Bianco P, Cao X, Frenette PS, Mao JJ, Robey PG, Simmons PJ et al. The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nat Med 2013; 19: 35–42.
Acknowledgements
This study was supported by grants from the Natural Science Foundation of Jiangsu (BK20170563), National Natural Science Foundation of China (No. 81373195), National Basic Research Program of China (2014CB541904) and Natural Science Foundation of Jiangsu (BK20150533).
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Rui, K., Lin, X., Tian, J. et al. Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy. Cell Mol Immunol 15, 82–84 (2018). https://doi.org/10.1038/cmi.2017.69
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DOI: https://doi.org/10.1038/cmi.2017.69