Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Message in a bottle from the tumor microenvironment: tumor-educated DCs instruct B cells to participate in immunosuppression

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

References

  1. Rosser EC, Mauri C . Regulatory B cells: origin, phenotype, and function. Immunity 2015; 42: 607–612.

    Article  CAS  PubMed  Google Scholar 

  2. Garaud S, Taher TE, Debant M, Burgos M, Melayah S, Berthou C et al. CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes. Cell Mol Immunol 2016; e-pub ahead of print 8 August 2016; doi:10.1038/cmi.2016.42.

    Article  Google Scholar 

  3. Mizoguchi A, Mizoguchi E, Takedatsu H, Blumberg RS, Bhan AK . Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 2002; 16: 219–230.

    CAS  Google Scholar 

  4. Schwartz M, Zhang Y, Rosenblatt JD . B cell regulation of the anti-tumor response and role in carcinogenesis. J Immunother Cancer 2016; 4: 40.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Liu J, Wang H, Yu Q, Zheng S, Jiang Y, Liu Y et al. Aberrant frequency of IL-10-producing B cells and its association with Treg and MDSC cells in non small cell lung carcinoma patients. Hum Immunol 2016; 77: 84–89.

    Article  CAS  PubMed  Google Scholar 

  6. Cai C, Zhang J, Li M, Wu ZJ, Song KH, Zhan TW et al. Interleukin 10-expressing B cells inhibit tumor-infiltrating T cell function and correlate with T cell Tim-3 expression in renal cell carcinoma. Tumour Biol 2016; 37: 8209–8218.

    Article  CAS  PubMed  Google Scholar 

  7. Ganti SN, Albershardt TC, Iritani BM, Ruddell A . Regulatory B cells preferentially accumulate in tumor-draining lymph nodes and promote tumor growth. Sci Rep 2015; 5: 12255.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Pylayeva-Gupta Y, Das S, Handler JS, Hajdu CH, Coffre M, Koralov SB et al. IL35-producing B cells promote the development of pancreatic neoplasia. Cancer Dis 2016; 6: 247–255.

    Article  CAS  Google Scholar 

  9. Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D et al. Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature 2015; 521: 94–98.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Ouyang FZ, Wu RQ, Wei Y, Liu RX, Yang D, Xiao X et al. Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma. Nat Commun 2016; 7: 13453.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kuang DM, Zhao Q, Xu J, Yun JP, Wu C, Zheng L . Tumor-educated tolerogenic dendritic cells induce CD3epsilon down-regulation and apoptosis of T cells through oxygen-dependent pathways. J Immunol 2008; 181: 3089–3098.

    Article  CAS  PubMed  Google Scholar 

  12. Vomhof-DeKrey EE, Yates J, Hagglof T, Lanthier P, Amiel E, Veerapen N et al. Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells. Proc Natl Acad Sci USA 2015; 112: 12474–12479.

    Article  CAS  PubMed  Google Scholar 

  13. Mion F, D’Inca F, Danelli L, Toffoletto B, Guarnotta C, Frossi B et al. Mast cells control the expansion and differentiation of IL-10-competent B cells. J Immunol 2014; 193: 4568–4579.

    Article  CAS  PubMed  Google Scholar 

  14. Qian L, Qian C, Chen Y, Bai Y, Bao Y, Lu L et al. Regulatory dendritic cells program B cells to differentiate into CD19hiFcgammaIIbhi regulatory B cells through IFN-beta and CD40L. Blood 2012; 120: 581–591.

    Article  CAS  PubMed  Google Scholar 

  15. Villa-Morales M, Fernandez-Piqueras J . Targeting the Fas/FasL signaling pathway in cancer therapy. Expert Opin Ther Targets 2012; 16: 85–101.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

Authors are supported by the Associazione Italiana Ricerca sul Cancro (AIRC), Progetti di Ricerca di Interesse Nazionale (PRIN), and Associazione Italiana Mastocitosi (ASIMAS).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Carlo E Pucillo.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mion, F., Tonon, S., Valeri, V. et al. Message in a bottle from the tumor microenvironment: tumor-educated DCs instruct B cells to participate in immunosuppression. Cell Mol Immunol 14, 730–732 (2017). https://doi.org/10.1038/cmi.2017.63

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/cmi.2017.63

This article is cited by

Search

Quick links