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Microbiota or short-chain fatty acids: which regulates diabetes?

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  1. Gao HX, Regier EE, Close KL . Prevalence of and trends in diabetes among adults in the United States, 1988–2012. J Diabetes 2016; 8: 8–9.

    PubMed  Google Scholar 

  2. Trowell HC . Dietary-fiber hypothesis of the etiology of diabetes mellitus. Diabetes 1975; 24: 762–765.

    Article  CAS  Google Scholar 

  3. Anderson JW, Bryant CA . Dietary fiber: diabetes and obesity. Am J Gastroenterol 1986; 81: 898–906.

    CAS  PubMed  Google Scholar 

  4. Marino E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J et al. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol 2017; 18: 552–562.

    Article  CAS  Google Scholar 

  5. Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity 2014; 40: 128–139.

    Article  CAS  Google Scholar 

  6. Chang PV, Hao L, Offermanns S, Medzhitov R . The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci USA 2014; 111: 2247–2252.

    Article  CAS  Google Scholar 

  7. Park J, Kim M, Kang SG, Jannasch AH, Cooper B, Patterson J et al. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol 2015; 8: 80–93.

    Article  CAS  Google Scholar 

  8. Kim M, Qie Y, Park J, Kim CH . Gut microbial metabolites fuel host antibody responses. Cell Host Microbe 2016; 20: 202–214.

    Article  CAS  Google Scholar 

  9. Kim CH, Park J, Kim M . Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation. Immune Netw 2014; 14: 277–288.

    Article  Google Scholar 

  10. Kim MH, Kang SG, Park JH, Yanagisawa M, Kim CH . Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology 2013; 145: 396–406 e1-10.

    Article  CAS  Google Scholar 

  11. Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat Commun 2015; 6: 6734.

    Article  CAS  Google Scholar 

  12. Wang A, Gu Z, Heid B, Akers RM, Jiang H . Identification and characterization of the bovine G protein-coupled receptor GPR41 and GPR43 genes. J Dairy Sci 2009; 92: 2696–2705.

    Article  CAS  Google Scholar 

  13. Fu CY, Liu L, Gao Q, Sui XY, Li FC . Cloning, molecular characterization, and spatial and developmental expression analysis of GPR41 and GPR43 genes in New Zealand rabbits. Animal 2017, 1–9.

  14. Louis P, Flint HJ, Michel C . How to manipulate the microbiota: prebiotics. Adv Exp Med Biol 2016; 902: 119–142.

    Article  Google Scholar 

  15. Park J, Goergen CJ, HogenEsch H, Kim CH . Chronically elevated levels of short-chain fatty acids induce T cell-mediated ureteritis and hydronephrosis. J Immunol 2016; 196: 2388–2400.

    Article  CAS  Google Scholar 

  16. Shi Y, Mu L . An expanding stage for commensal microbes in host immune regulation. Cell Mol Immunol 2017; 14: 339–348.

    Article  CAS  Google Scholar 

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This study was supported partly from NIH grants (R01AI074745, R01DK076616, R01AI080769 and R01AI121302).

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Correspondence to Chang H Kim.

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Kim, C. Microbiota or short-chain fatty acids: which regulates diabetes?. Cell Mol Immunol 15, 88–91 (2018).

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