This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Features of Metabolite Changes in Disease Evolution in Cholecystolithiasis
Digestive Diseases and Sciences Open Access 09 November 2023
-
Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids
Cellular & Molecular Immunology Open Access 13 April 2021
-
Hyperglycemia exacerbates acetaminophen-induced acute liver injury by promoting liver-resident macrophage proinflammatory response via AMPK/PI3K/AKT-mediated oxidative stress
Cell Death Discovery Open Access 19 July 2019
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gao HX, Regier EE, Close KL . Prevalence of and trends in diabetes among adults in the United States, 1988–2012. J Diabetes 2016; 8: 8–9.
Trowell HC . Dietary-fiber hypothesis of the etiology of diabetes mellitus. Diabetes 1975; 24: 762–765.
Anderson JW, Bryant CA . Dietary fiber: diabetes and obesity. Am J Gastroenterol 1986; 81: 898–906.
Marino E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J et al. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol 2017; 18: 552–562.
Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity 2014; 40: 128–139.
Chang PV, Hao L, Offermanns S, Medzhitov R . The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci USA 2014; 111: 2247–2252.
Park J, Kim M, Kang SG, Jannasch AH, Cooper B, Patterson J et al. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol 2015; 8: 80–93.
Kim M, Qie Y, Park J, Kim CH . Gut microbial metabolites fuel host antibody responses. Cell Host Microbe 2016; 20: 202–214.
Kim CH, Park J, Kim M . Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation. Immune Netw 2014; 14: 277–288.
Kim MH, Kang SG, Park JH, Yanagisawa M, Kim CH . Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology 2013; 145: 396–406 e1-10.
Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat Commun 2015; 6: 6734.
Wang A, Gu Z, Heid B, Akers RM, Jiang H . Identification and characterization of the bovine G protein-coupled receptor GPR41 and GPR43 genes. J Dairy Sci 2009; 92: 2696–2705.
Fu CY, Liu L, Gao Q, Sui XY, Li FC . Cloning, molecular characterization, and spatial and developmental expression analysis of GPR41 and GPR43 genes in New Zealand rabbits. Animal 2017, 1–9.
Louis P, Flint HJ, Michel C . How to manipulate the microbiota: prebiotics. Adv Exp Med Biol 2016; 902: 119–142.
Park J, Goergen CJ, HogenEsch H, Kim CH . Chronically elevated levels of short-chain fatty acids induce T cell-mediated ureteritis and hydronephrosis. J Immunol 2016; 196: 2388–2400.
Shi Y, Mu L . An expanding stage for commensal microbes in host immune regulation. Cell Mol Immunol 2017; 14: 339–348.
Acknowledgements
This study was supported partly from NIH grants (R01AI074745, R01DK076616, R01AI080769 and R01AI121302).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no conflict of interest.
Rights and permissions
About this article
Cite this article
Kim, C. Microbiota or short-chain fatty acids: which regulates diabetes?. Cell Mol Immunol 15, 88–91 (2018). https://doi.org/10.1038/cmi.2017.57
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/cmi.2017.57
This article is cited by
-
Features of Metabolite Changes in Disease Evolution in Cholecystolithiasis
Digestive Diseases and Sciences (2024)
-
Correlation of Differentially Expressed lncRNAs with Intestinal Flora Imbalance, Small Intestinal Permeability, and Glucose Uptake in T2DM Mice
Applied Biochemistry and Biotechnology (2024)
-
New dawn of ginsenosides: regulating gut microbiota to treat metabolic syndrome
Phytochemistry Reviews (2024)
-
Review of the Health Benefits of Cereals and Pseudocereals on Human Gut Microbiota
Food and Bioprocess Technology (2023)
-
Similar bacterial signatures in the gut microbiota of type 1 and type 2 diabetes patients and its association with G protein-coupled receptor 41 and 43 gene expression
Journal of Diabetes & Metabolic Disorders (2022)