Figure 3 | Cellular & Molecular Immunology

Figure 3

From: Lineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape

Figure 3

Histone methylation in signature genes that show progressive expression. (A) Box plots showing normalized tag density (after subtraction from naïve) of permissive H3K4me3 or repressive H3K27me3 in progressively upregulated signature genes with at least 1.5-fold change in purple cluster of Figure 2, panel A. (B) Box plots showing normalized tag density (after subtraction from naïve) of permissive H3K4me3 or repressive H3K27me3 in progressively downregulated signature genes with at least 1.5-fold change in red cluster of Figure 2, panel A. Color of lines in panels (A) and (B) represent a change of tag density from naïve to stem cell memory T cells and stem cell memory to average of central and effector memory T cells (naïve T cell → TSCM → average of TCM and TEM) in the following directions: red (down–down), yellow (down–up), blue (up–down), purple (up–up), and green (other) where “up” means tag density difference between the two compared subset is >0, and “down” means tag density difference between the two compared subset is <0, and “other” means no difference in tag density in at least one of the two comparisons. In each panel, we excluded genes that have zero normalized tag density in all cell subsets.

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