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Ubiquitin-mediated NFκB degradation pathway

Cellular & Molecular Immunology volume 12, pages 653–655 (2015)Cite this article

Abstract

The nuclear factor κB (NFκB) transcription factor plays critical roles in inflammation and immunity. The dysregulation of NFκB is associated with inflammatory and autoimmune diseases and cancer. NFκB activation is negatively regulated by the ubiquitin-dependent proteasomal degradation pathway. In the present review, we discuss recent advances in our understanding of how ubiquitin ligases regulate the NFκB degradation pathway.

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Acknowledgements

This work was supported by the Jiangsu Province Natural Science Foundation (SBK201320232); the National Science Foundation of China (31271272, 31071030); and the Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry.

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Authors and Affiliations

  1. Institute of Life Sciences, Jiangsu University, Zhenjiang, China

    Huimin Xu, Mengli You, Haifeng Shi & Yongzhong Hou

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  1. Huimin Xu
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  2. Mengli You
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Correspondence to Yongzhong Hou.

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Xu, H., You, M., Shi, H. et al. Ubiquitin-mediated NFκB degradation pathway. Cell Mol Immunol 12, 653–655 (2015). https://doi.org/10.1038/cmi.2014.99

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