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Hepatic effector CD8+ T-cell dynamics

Cellular & Molecular Immunology volume 12, pages 269–272 (2015)Cite this article

Abstract

CD8+ T cells play a critical role in hepatitis B virus (HBV) pathogenesis. During acute, self-limited infections, these cells are instrumental to viral clearance; in chronic settings, they sustain repetitive cycles of hepatocellular necrosis that promote hepatocellular carcinoma development. Both CD8+ T-cell defensive and destructive functions are mediated by antigen-experienced effector cells and depend on the ability of these cells to migrate to the liver, recognize hepatocellular antigens and perform effector functions. Understanding the signals that modulate the spatiotemporal dynamics of CD8+ T cells in the liver, particularly in the context of antigen recognition, is therefore critical to gaining insight into the pathogenesis of acute and chronic HBV infection. Here, we highlight recent data on how effector CD8+ T cells traffic within the liver, and we discuss the potential for novel imaging techniques to shed light on this important aspect of HBV pathogenesis.

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Acknowledgements

We thank R Serra for secretarial assistance; L Ganzer, D Inverso and L G Guidotti for help with the preparation of Figures and Movies; and L Sironi, G Chirico and all the members of the Iannacone laboratory for helpful discussions. This work was supported by ERC (grant 281648), Italian Association for Cancer Research (grant 9965) and a Career Development Award from the Giovanni Armenise-Harvard Foundation. Supplementary Information accompanies the paper on Cellular & Molecular Immunology's website (http://www.nature.com/cmi).

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  1. Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy

    Matteo Iannacone

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Correspondence to Matteo Iannacone.

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Supplementary Information accompanies the paper on Cellular & Molecular Immunology's website. (http://www.nature.com/cmi).

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Iannacone, M. Hepatic effector CD8+ T-cell dynamics. Cell Mol Immunol 12, 269–272 (2015). https://doi.org/10.1038/cmi.2014.78

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