Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Sema 4D/CD100-plexin B is a multifunctional counter-receptor

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1


  1. Bougeret C, Mansur IG, Dastot H, Schmid M, Mahouy G, Bensussan A et al. Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation. J Immunol 1992; 148: 318–323.

    CAS  PubMed  Google Scholar 

  2. Kolodkin AL, Matthes DJ, Goodman CS . The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell 1993; 75: 1389–1399.

    Article  CAS  Google Scholar 

  3. Hall KT, Boumsell L, Schultze JL, Boussiotis VA, Dorfman DM, Cardoso AA et al. Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc Natl Acad Sci USA 1996; 93: 11780–11785.

    Article  CAS  Google Scholar 

  4. Takamatsu H, Okuno T, Kumanogoh A . Regulation of immune cell responses by semaphorins and their receptors. Cell Mol Immunol 2010; 7: 83–88.

    Article  Google Scholar 

  5. Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H et al. Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Immunity 2000; 13: 621–631.

    Article  CAS  Google Scholar 

  6. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H et al. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 1999; 99: 71–80.

    Article  CAS  Google Scholar 

  7. Masuda K, Furuyama T, Takahara M, Fujioka S, Kurinami H, Inagaki S . Sema4D stimulates axonal outgrowth of embryonic DRG sensory neurones. Genes Cells 2004; 9: 821–829.

    Article  CAS  Google Scholar 

  8. Witherden DA, Watanabe M, Garijo O, Rieder SE, Sarkisyan G, Cronin SJ et al. The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal gammadelta T cell function. Immunity 2012; 37: 314–325.

    Article  CAS  Google Scholar 

  9. Bonneville M . Semaphorins: new cues for skin healing by gammadelta T cells. Immunity 2012; 37: 194–196.

    Article  CAS  Google Scholar 

  10. Witherden DA, Verdino P, Rieder SE, Garijo O, Mills RE, Teyton L et al. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science 2010; 329: 1205–1210.

    Article  CAS  Google Scholar 

  11. Komori HK, Witherden DA, Kelly R, Sendaydiego K, Jameson JM, Teyton L et al. Cutting edge: dendritic epidermal gammadelta T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding. J Immunol 2012; 188: 2972–2976.

    Article  CAS  Google Scholar 

Download references


This study was supported by The National Natural Science Foundation of China (No. 30930087).

Author information

Authors and Affiliations


Corresponding author

Correspondence to Boquan Jin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhang, Y., Liu, B., Ma, Y. et al. Sema 4D/CD100-plexin B is a multifunctional counter-receptor. Cell Mol Immunol 10, 97–98 (2013).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links