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Sema 4D/CD100-plexin B is a multifunctional counter-receptor

Cellular & Molecular Immunology volume 10, pages 97–98 (2013)Cite this article

The discovery of Sema 4D can be dated to 1992, when Boumsell's team reported a novel 150-kDa glycoprotein dimer. It was expressed on T lymphocytes that had been activated with CD3 monoclonal antibody or phytohaemagglutinin.1 Hence, this molecule has been designated CD100 by the International Workshop on Human Leukocyte Differentiation Antigen. In 1996, 3 years after the discovery of the semaphorin family,2 the CD100 gene was cloned and identified as the first semaphorin with immune system functions.3 Unlike the prototypical semaphorins, which are neuronal chemorepellents, Sema 4D/CD100 together with Sema 3A, Sema 4A, Sema 6D and Sema 7A have been described as ‘immune semaphorins’, because they are expressed on T cells, B cells, natural killer cells and dendritic cells, and exhibit a variety of immunological functions.4

Recently, Witherden et al.8 demonstrated that the interaction of Sema 4D/CD100 with plexin B2 plays a key role in activating skin-resident γδ T cells (DETCs) in mice to respond to tissue damage (Figure 1c). The morphological changes in DETCs that precede cutaneous wound healing appear to be associated with the activation of key actin regulators in response to Sema 4D/CD100's binding with its ligand. This is the first example indicating that Sema 4D/CD100 is not only a ligand for plexin B1 or CD72 but also a direct signaling receptor in mediating Sema 4D/CD100-plexin B's biological functions. It is not surprising to identify Sema 4D/CD100-plexin B as a counter-receptor, because many counter-receptors have already been well documented in the B7-CD28 family and TNF–TNFR superfamilies.

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Acknowledgements

This study was supported by The National Natural Science Foundation of China (No. 30930087).

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  1. Department of Immunology, The Fourth Military Medical University, Xi'an, China

    Yusi Zhang, Bei Liu, Ying Ma & Boquan Jin

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  1. Yusi Zhang
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Correspondence to Boquan Jin.

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Zhang, Y., Liu, B., Ma, Y. et al. Sema 4D/CD100-plexin B is a multifunctional counter-receptor. Cell Mol Immunol 10, 97–98 (2013). https://doi.org/10.1038/cmi.2012.65

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