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The role of the T follicular helper cells in allergic disease

Cellular & Molecular Immunology volume 9, pages 386–389 (2012)Cite this article

Abstract

T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching to IgE. Recent studies have questioned whether the germinal centre is the main site of IgE class switching or IgE affinity maturation. In this review, I will examine the evidence that these cells are responsible for regulating IgE class switching and the relationship between Tfh cells and T helper 2 (Th2) effector cells.

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  1. Department of Microbiology and Immunology Programme, National University of Singapore, Singapore

    DM Kemeny

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Kemeny, D. The role of the T follicular helper cells in allergic disease. Cell Mol Immunol 9, 386–389 (2012). https://doi.org/10.1038/cmi.2012.31

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