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Germinal center kinases in immune regulation

Cellular & Molecular Immunology volume 9, pages 439–445 (2012)Cite this article

Abstract

Germinal center kinases (GCKs) participate in a variety of signaling pathways needed to regulate cellular functions including apoptosis, cell proliferation, polarity and migration. Recent studies have shown that GCKs are participants in both adaptive and innate immune regulation. However, the differential activation and regulatory mechanisms of GCKs, as well as upstream and downstream signaling molecules, remain to be fully defined. It remains unresolved whether and how GCKs may cross-talk with existing signaling pathways. This review stresses the progresses in research of GCKs relevant to the immune system.

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Acknowledgements

This work was supported by the 973 Program of the Ministry of Science and Technology of China (2010CB529700 and 2012CB910204), the National Natural Science Foundation of China (NSFC10979005 and NSFC30970566) and the Science and Technology Commission of Shanghai Municipality (11JC14140000). Dr ZZ is a scholar of the Hundred Talents Program of the Chinese Academy of Sciences. Dr Greene is supported by grants from the NIH, NCI, the Abramson Family Research Institute and the BCRF.

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Authors and Affiliations

  1. Department of Trauma and Orthopaedics, General Hospital of Jinan Military Region, Jinan, China

    Hailei Yin

  2. No. 401 Hospital of People Liberation Army, Qingdao, China

    Hailei Yin

  3. State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

    Zhubing Shi, Shi Jiao, Cuicui Chen, Wenjia Wang & Zhaocai Zhou

  4. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Mark I Greene

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  1. Hailei Yin
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  2. Zhubing Shi
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  3. Shi Jiao
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Correspondence to Zhaocai Zhou.

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Yin, H., Shi, Z., Jiao, S. et al. Germinal center kinases in immune regulation. Cell Mol Immunol 9, 439–445 (2012). https://doi.org/10.1038/cmi.2012.30

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