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Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance

Cellular & Molecular Immunology volume 9, pages 113–122 (2012)Cite this article

Abstract

E3 ubiquitin ligases play a crucial role in regulating immune receptor signaling and modulating immune homeostasis and activation. One emerging family of such E3s is the Pelle-interacting (Peli) proteins, characterized by the presence of a cryptic forkhead-associated domain involved in substrate binding and an atypical RING domain mediating formation of both lysine (K) 63- and K48-linked polyubiquitin chains. A well-recognized function of Peli family members is participation in the signal transduction mediated by Toll-like receptors (TLRs) and IL-1 receptor. Recent gene targeting studies have provided important insights into the in vivo functions of Peli1 in the regulation of TLR signaling and inflammation. These studies have also extended the biological functions of Peli1 to the regulation of T-cell tolerance. Consistent with its immunoregulatory functions, Peli1 responds to different immune stimuli for its gene expression and catalytic activation. In this review, we discuss the recent progress, as well as the historical perspectives in the regulation and biological functions of Peli.

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Acknowledgements

The research of S-CS is supported by grants from the US National Institutes of Health (AI057555, AI064639 and GM84459) and the GS Hogan Gastrointestinal Cancer Fund.

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  1. Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Wei Jin

  2. Department of Immunology, The University of Texas MD Anderson Cancer Center, New York, NY 10065, USA

    Mikyoung Chang & Shao-Cong Sun

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Jin, W., Chang, M. & Sun, SC. Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance. Cell Mol Immunol 9, 113–122 (2012). https://doi.org/10.1038/cmi.2011.60

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