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Novel trends in celiac disease

Cellular & Molecular Immunology volume 8, pages 121–125 (2011)Cite this article

Abstract

Celiac disease (CD) is one of the most common food intolerances in developed world. It affects genetically susceptible individuals and has severe consequences if it remains undiagnosed. A disease known for more than a century, it is still the focus for experts from various fields of research and development. Geneticists, pathologists, immunologists, food engineers and dieticians share their knowledge and expertise to improve the conditions of CD patients. With new insights in the pathomechanism of gluten processing and antigen presentation in CD, it was possible to improve the diagnostic antigen mimicking the primary epitope in CD. These celiac neo-epitopes are comprised of a complex of gliadin peptides crosslinked with transglutaminase (tTg). They are an early diagnostic marker for CD which occurs up to 6 months earlier than classical markers known to miss a certain amount of CD patients.

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Authors and Affiliations

  1. AESKU.KIPP Institute, Wendelsheim, Germany

    Torsten Matthias, Sandra Neidhöfer & Sandra Reuter

  2. AESKU.Diagnostics GmbH & Co. KG, Wendelsheim, Germany

    Sascha Pfeiffer & Kai Prager

  3. Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA, USA

    M Eric Gershwin

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  1. Torsten Matthias
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Correspondence to Torsten Matthias.

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Matthias, T., Neidhöfer, S., Pfeiffer, S. et al. Novel trends in celiac disease. Cell Mol Immunol 8, 121–125 (2011). https://doi.org/10.1038/cmi.2010.68

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