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IL-17 signaling in host defense and inflammatory diseases

Cellular & Molecular Immunology volume 7, pages 328–333 (2010)Cite this article

Abstract

Interleukin (IL)-17, the signature cytokine secreted by T helper (Th) 17 cells, plays important roles in host defense against extracellular bacterial infection and fungal infection and contributes to the pathogenesis of various autoimmune inflammatory diseases. Here we review the recent advances in IL-17-mediated functions with emphasis on the studies of IL-17-mediated signal transduction, providing perspective on potential drug targets for the treatment of autoimmune inflammatory diseases.

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Acknowledgements

This work was supported by grants from the American Asthma Foundation and the Multiple Sclerosis Society to Xiaoxia Li, and by the National Natural Science Foundation of China (Nos. 30930084, 30871298 and 30928025), 973 Program (No. 2010CB529705), Chinese Academy of Sciences (Nos. KSCX2-YW-R-146 and KSCX1-YW-22) and Science and Technology Commission of Shanghai Municipality (No. 08PJ14110).

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  1. The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Youcun Qian

  2. Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

    Zizhen Kang, Caini Liu & Xiaoxia Li

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  1. Youcun Qian
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Qian, Y., Kang, Z., Liu, C. et al. IL-17 signaling in host defense and inflammatory diseases. Cell Mol Immunol 7, 328–333 (2010). https://doi.org/10.1038/cmi.2010.27

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