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Bisphenol A in combination with TNF-α selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity

Cellular & Molecular Immunology volume 7, pages 227–234 (2010)Cite this article

Abstract

Bisphenol A (BPA) is a monomer used in manufacturing a wide range of chemical products, including epoxy resins and polycarbonate. BPA, an important endocrine disrupting chemical that exerts estrogen-like activities, is detectable at nanomolar levels in human serum worldwide. The pregnancy associated doses of 17β-estradiol (E2) plus tumor-necrosis factor-α (TNF-α) induce distorted maturation of human dendritic cells (DCs) that result in an increased capacity to induce T helper (Th) 2 responses. The current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs, thereby polarizing the subsequent Th response. In the presence of TNF-α, BPA treatment enhanced the expression of CC chemokine ligand 1 (CCL1) in DCs. In addition, DCs exposed to BPA/TNF-α produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation, and preferentially induced Th2 deviation. BPA exerts the same effect with E2 at the same dose (0.01–0.1 µΜ) with regard to DC-mediated Th2 polarization. These findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions.

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Acknowledgements

This work was supported in part by the Nursing Foundation for Science Development and Innovation 09KMM06 from Chinese PLA General Hospital, Grants-in-Aid 21791572, 21791473 and 20591190 from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, and research grants from the Kansai Medical University (Research grant C), the Osaka Cancer Research Foundation (2010), and the Princess Takamatsu Cancer Research Fund (09-24104).

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Authors and Affiliations

  1. Department of Neurosurgery, XuanWu Hospital, Capital University of Medical Science, Beijing, China

    Hongchuan Guo, Qiuhang Zhang & Feng Ling

  2. Department of Oncology, Chinese PLA General Hospital, Beijing, China

    Tianyi Liu & Shunchang Jiao

  3. Department of Stem Cell Biology and Regenerative Medicine, Graduate School of Medical Science, Kansai Medical University, Osaka, Japan

    Yasushi Uemura & Yayoi Narita

  4. Department of Blood Transfusion, Chinese PLA General Hospital, Beijing, China

    Deqing Wang & Zilin Lin

  5. Department of Obstetrics and Gynecology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan

    Motoharu Suzuki & Osamu Ishihara

  6. Department of Biomedical Research Center, Division of Analytical Science, Faculty of Medicine, Saitama Medical University, Moroyama, Japan

    Narumi Hirosawa & Yasushi Sakamoto

  7. Department of Anesthesiology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan

    Yasuko Ichihara & Hirosato Kikuchi

  8. Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

    Satoru Senju

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Correspondence to Tianyi Liu or Yasushi Uemura.

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Guo, H., Liu, T., Uemura, Y. et al. Bisphenol A in combination with TNF-α selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity. Cell Mol Immunol 7, 227–234 (2010). https://doi.org/10.1038/cmi.2010.14

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