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H. pylori Escape Host Immunoreaction Through Inhibiting ILK Expression by VacA

Cellular & Molecular Immunology volume 6, pages 191–197 (2009)Cite this article

Abstract

Helicobacter pylori (H. pylori) persistently colonizes the gastric mucosa despite a vigorous immune response. Vacuolating cytotoxin secreted by H. pylori has turned out to be a potent immunomodulatory toxin, but the signal transduction pathways involved has not been studied in macrophages. We observed in this study that vacA-deficient H. pylori induced significantly higher expression of integrin-linked kinase (ILK) and endothelial nitric oxygen synthase (eNOS), and significantly more production of reactive oxygen species (ROS) in monocyte/macrophage-like U937 cells, as compared with isogenic vacA+H. pylori. The expression of eNOS mRNA in U937 cells overexpressing ILK was markedly increased compared with those transfected with empty vectors. Thus, vacA-deficient H. pylori appears to upregulate ILK expression, which modulates the expression of eNOS and as a result, stimulates the production of ROS. It is VacA that prevents such a process by inhibiting ILK expression, helping H. pylori escape host immunoreaction. This mechanism explains, at least in part, persistent infection of H. pylori in the stomach.

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Author notes

  1. Jianping Yuan and Ping Li: These two authors contribute equally to this work as first authors.

Authors and Affiliations

  1. Department of Medical Microbiology and Parasitology, Shanghai Jiaotong University, School of Medicine, Shanghai, 200025, China

    Jianping Yuan, Ping Li, Jing Tao, Xiaodong Shi, Baoyu Hu & Xiaokui Guo

  2. Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, 02114, MA, USA

    Jianping Yuan, Ping Li, Jing Tao, Xiaodong Shi, Baoyu Hu & Xiaokui Guo

  3. Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, 02129, MA, USA

    Huabiao Chen

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  1. Jianping Yuan
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  2. Ping Li
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  3. Jing Tao
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  4. Xiaodong Shi
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  5. Baoyu Hu
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  6. Huabiao Chen
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  7. Xiaokui Guo
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Correspondence to Jianping Yuan or Xiaokui Guo.

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Yuan, J., Li, P., Tao, J. et al. H. pylori Escape Host Immunoreaction Through Inhibiting ILK Expression by VacA. Cell Mol Immunol 6, 191–197 (2009). https://doi.org/10.1038/cmi.2009.26

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  • DOI: https://doi.org/10.1038/cmi.2009.26

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