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Premetastatic milieu explained by TLR4 agonist-mediated homeostatic inflammation

Cellular & Molecular Immunology volume 7, pages 94–99 (2010)Cite this article

Abstract

Accumulating evidence suggests that Toll-like receptor 4 (TLR4), a sensor for danger signals, is expressed not only in immune cells, but also in resident epithelial cells, and appears to participate in tissue homeostasis. To explain the premetastatic microenvironment created by the newly discovered endogenous TLR4 ligands, I propose a hypothesis of homeostatic inflammation that includes the classical danger hypothesis.

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Acknowledgements

I thank Dr Y. Sakurai, Dr T. Tomita and Dr F. Tsukahara, and Ms S. Ishibashi for help with experiments. This work was partly supported by Grants-in-Aid for Scientific Research from the Japanese government (No. 21117008) (homeostatic inflammation study group) to YM.

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  1. Department of Pharmacology, Tokyo Women’s Medical University, Tokyo, Japan

    Yoshiro Maru

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Maru, Y. Premetastatic milieu explained by TLR4 agonist-mediated homeostatic inflammation. Cell Mol Immunol 7, 94–99 (2010). https://doi.org/10.1038/cmi.2009.113

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