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Regulation of immune cell responses by semaphorins and their receptors

Cellular & Molecular Immunology volume 7, pages 83–88 (2010)Cite this article

Abstract

Semaphorins were originally identified as axon guidance factors involved in the development of the neuronal system. However, accumulating evidence indicates that several members of semaphorins, so-called ‘immune semaphorins’, are crucially involved in various phases of immune responses. These semaphorins regulate both immune cell interactions and immune cell trafficking during physiological and pathological immune responses. Here, we review the following two functional aspects of semaphorins and their receptors in immune responses: their functions in cell–cell interactions and their involvement in immune cell trafficking.

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Acknowledgements

This study was supported by research grants from the JSPS Research Fellowships for Young Scientists (H. Takamatsu), the Ministry of Education, Culture, Sports, Science and Technology of Japan, grants-in-aid from the Ministry of Health, Labor, and Welfare, the program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (A. Kumanogoh), the Target Protein Research Program of the Japan Science and Technology Agency (A. Kumanogoh), Uehara Memorial Foundation (A. Kumanogoh) and Takeda Scientific Foundation (A. Kumanogoh). The authors have no conflicting financial interests.

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  1. Department of Immunopathology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

    Hyota Takamatsu, Tatsusada Okuno & Atsushi Kumanogoh

  2. World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

    Hyota Takamatsu, Tatsusada Okuno & Atsushi Kumanogoh

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  1. Hyota Takamatsu
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Takamatsu, H., Okuno, T. & Kumanogoh, A. Regulation of immune cell responses by semaphorins and their receptors. Cell Mol Immunol 7, 83–88 (2010). https://doi.org/10.1038/cmi.2009.111

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