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A novel interface consisting of homologous immunoglobulin superfamily members with multiple functions

Cellular & Molecular Immunology volume 7, pages 11–19 (2010)Cite this article

Abstract

Immunoglobulin superfamily (IgSF) members account for a large proportion of cell adhesion molecules that perform important immunological functions, including recognizing a variety of counterpart molecules on the cell surface or extracellular matrix. The findings that CD155/poliovirus receptor (PVR) and CD112/nectin-2 are the ligands for CD226/platelet and T-cell activation antigen 1 (PTA1)/DNAX accessory molecular-1 (DNAM-1), CD96/tactile and Washington University cell adhesion molecule (WUCAM) and that CD226 is physically and functionally associated with lymphocyte function-associated antigen-1 (LFA-1) on natural killer (NK) and activated T cells have largely expanded our knowledge about the functions of CD226, CD96, WUCAM and LFA-1 and their respective ligands, CD155, CD112, intercellular adhesion molecule (ICAM)-1 and junctional adhesion molecule (JAM)-1. The interactions of these receptors and their ligands are involved in many key functions of immune cells including naive T cells, cytotoxic T cells, NK cells, NK T cells, monocytes, dendritic cells, mast cells and platelets/megakaryocytes.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 30801003, 30972683 and 30901310).

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  1. Department of Immunology, the Fourth Military Medical University, Xi’an, China

    Zhuwei Xu & Boquan Jin

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Correspondence to Boquan Jin.

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Xu, Z., Jin, B. A novel interface consisting of homologous immunoglobulin superfamily members with multiple functions. Cell Mol Immunol 7, 11–19 (2010). https://doi.org/10.1038/cmi.2009.108

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