Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The Classical and Regulatory Functions of C1q in Immunity and Autoimmunity

Abstract

A classical function of C1q is to bind immune complexes and initiate complement activation producing membrane lytic complexes, opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when C1q binds some other ligands. Besides complement activation, C1q also regulates cell differentiation, adhesion, migration, activation and survival. C1q deficiency is associated with autoimmunity as well as increased susceptibility to infections. In this article, we discuss the basic properties of C1q, its expression, and classical and regulatory functions.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Jinhua Lu.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lu, J., Teh, B., Wang, L. et al. The Classical and Regulatory Functions of C1q in Immunity and Autoimmunity. Cell Mol Immunol 5, 9–21 (2008). https://doi.org/10.1038/cmi.2008.2

Download citation

Keywords

  • C1q
  • macrophage
  • dendritic cell
  • apoptotic cell
  • autoimmunity

Further reading

Search

Quick links