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Oral contrast enhances the resolution of in-life NIS reporter gene imaging

Cancer Gene Therapy volume 20, pages 638–641 (2013)Cite this article

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Abstract

Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotracer uptake in NIS-transduced organs.

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Acknowledgements

We thank Suzanne Greiner (Mayo Clinic) for her veterinary expertise, Michael K O’Connor (Radiology, Mayo Clinic) for critical review of the manuscript, Tracy Decklever and Brad Kemp (Radiology, Mayo Clinic) of the Mayo Clinic Small Animal Imaging Core. This work was supported by the Mayo Foundation and grants from the National Institutes of Health (R01CA129193, R01CA100634, R01CA129966).

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Authors and Affiliations

  1. Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA

    L Suksanpaisan, L Pham, S J Russell & K-W Peng

  2. Department of Genetics, Cell Biology and Development, University of Minnesota, MN, USA

    S McIvor

  3. Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA

    K-W Peng

Authors
  1. L Suksanpaisan
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  2. L Pham
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  3. S McIvor
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  4. S J Russell
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Correspondence to K-W Peng.

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Competing interests

SJR and KWP are co-founders of Imanis Life Sciences, a reporter gene imaging company. SJR, KWP and Mayo Clinic own equity in Imanis.

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Supplementary Information accompanies the paper on Cancer Gene Therapy website

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Suksanpaisan, L., Pham, L., McIvor, S. et al. Oral contrast enhances the resolution of in-life NIS reporter gene imaging. Cancer Gene Ther 20, 638–641 (2013). https://doi.org/10.1038/cgt.2013.57

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  • DOI: https://doi.org/10.1038/cgt.2013.57

Keywords

  • NIS
  • perigastric
  • reporter gene
  • oral contrast
  • barium sulfate

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