Figure 7

From: Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling

Figure 7

SNX2 gene expression is decreased in CRC tumors. (a) SNX2 and SNX1 mRNA levels (unpaired, left panels; paired, right panels) in 41 normal (N) and 456 CRC tumor (T) samples from patients. Data were analyzed using Mann–Whitney (unpaired) or Wilcoxon's (paired) nonparametric test. (b) SNX2 and SNX1 mRNA levels categorized according to tumor stage. Data were analyzed using Kruskal–Wallis multiple comparison tests. Although no tumor stage shows significant difference with the others, all stages are significantly different from normal samples (P<0.0001). (c) Kaplan–Meier analysis of high 25% and low 25% SNX2 and SNX1 mRNA expression levels correlated with patient survival. Data were analyzed using the Mantel–Cox (log-rank) test and P-values and calculated Mantel–Haenszel HRs are indicated (see text). (d) Correlation between SNX2 and SNX1 mRNA expression levels in 497 samples. The Spearman's coefficient r and P-value are indicated. ****P<0.0001. See Supplementary Figure 2 for further analyses.