Figure 4 | Cell Death & Disease

Figure 4

From: Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease

Figure 4

Mutation of Parp rescues parkin mutant phenotypes. (a) ParpCH1/+ mutation rescues the thoracic defect (asterisks, χ2 two-tailed, 95% confidence intervals), (b) climbing ability (mean±S.D.; asterisks, two-tailed unpaired t-test), and (c) increases survival in parkin mutants (n=130 for control, n=122 for parkin and n=128 for parkin, ParpCH1/+; asterisks, log-rank, Mantel-Cox). (d) Anti-TH staining showing cell bodies of PPL1 neurons. Representative images for each genotype are shown. (e) ParpCH1/+ mutation prevents the loss of dopaminergic neurons in the PPL1 cluster of parkin mutant flies (mean±S.E.M.; asterisks, one-way ANOVA with Bonferroni’s multiple comparison test). Genotypes: control: w1118; parkin: park25/park25; parkin, parpCH1/+: park25, ParpCH1/park25

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