Figure 2 | Cell Death & Disease

Figure 2

From: Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease

Figure 2

An NAM-enhanced diet blocks neurodegeneration in parkin mutants. (a) Representative images of normal and defective thorax in parkin mutants, the arrow points to a thoracic defect. (b) Dietary supplementation with NAM (5 mM) rescues the thoracic defects of parkin mutants (asterisks, χ2 two-tailed test, 95% confidence intervals). (c) Schematic diagram of a fly brain in sagittal orientation indicating the PPL1 cluster of dopaminergic neurons (red). (d) Anti-TH staining showing cell bodies of PPL1 neurons. Representative images for each condition are shown, arrows indicate individual PPL1 cluster neurons in a control animal. (e) Dietary supplementation with NAM (5 mM) rescues the loss of dopaminergic neurons in the PPL1 cluster of parkin mutant flies. (mean±S.E.M.; asterisks, two-tailed unpaired t-test). Genotypes: control: w1118; parkin: park25/park25

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