Figure 2 | Cell Death & Disease

Figure 2

From: Tsc1 expression by dendritic cells is required to preserve T-cell homeostasis and response

Figure 2

Tsc1 in DCs prevents spontaneous T-cell activation in vivo. (a) Expression of CD44 and CD62L on splenic CD4+Foxp3 and CD8+Foxp3 T cells. (b) Absolute number of CD44CD62L+ naive T cells in the spleen (n=4). (c) Ki67 staining of splenic T cells. (d) Intracellular staining of cytokines in splenic CD4+Foxp3 and CD8+Foxp3 T cells, stimulated with phorbol myristate acetate and ionomycin for 4 h. All mice analyzed were 6 week old. *P<0.05, **P<0.01; error bars represent S.D.; all data are representative of at least three independent experiments

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