Figure 9 | Cell Death & Disease

Figure 9

From: Cancer-derived immunoglobulin G promotes tumor cell growth and proliferation through inducing production of reactive oxygen species

Figure 9

A schematic model of cancer-derived IgG to enhance cell growth and proliferation through inducing the production of a low level of ROS. Based on our findings, we propose the following mechanism. The interaction between IgG and RACK1, RAN and PRDX1 prompted us to explore the mechanism of action of cancer-derived IgG in cell growth and oxidative stress. Cancer-derived IgG decreased cellular total antioxidant capacity including activities of some antioxidant enzymes (SOD, CAT, GR and GPx), the expression level of PRDX1 and GSH content. The decreased total antioxidant capacity in turn induces production of a low level of intracellular ROS that activates MAPK/ERK signaling pathway to enhance growth and proliferation of cancer cells

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