Figure 7 | Cell Death & Disease

Figure 7

From: Cancer-derived immunoglobulin G promotes tumor cell growth and proliferation through inducing production of reactive oxygen species

Figure 7

IgG induced the production of ROS to promote tumor growth in vivo. (a) Mean volumes (n=6 per group) of tumors formed in the bilateral groin of BALB/c nude mice injected with controls shRNA cells or IGHG1 shRNA cells or IGHG1 shRNA cells and H2O2 (error bar indicates S.E.M.). (b) Gross anatomy, H&E staining (scale bar, 20 μm), DHE and DCF staining (scale bar, 200 μm) of tumors from the above different groups of mice. DHE and DCF mean densities were analyzed in the right panel. (c) T-AOC of tumors tissues from the above different groups of mice was measured. (d) MDA contents of tumor tissues from the above different groups of mice were measured. The above data shown are the mean±S.D. of three independent experiments (*P<0.05). (e) The tissue homogenate of tumors from the above different groups of mice were fractionated by SDS-PAGE and blotted with anti-p-ERK antibodies

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