Figure 3 | Cell Death & Disease

Figure 3

From: Preferential control of induced regulatory T cell homeostasis via a Bim/Bcl-2 axis

Figure 3

Intrinsic vulnerability of Bim, Bcl-2 and Bcl-xl balance in iTregs. (a and b) iTregs and activated Tconv were prepared as in Figure 2. mRNA was isolated from either freshly sorted iTregs (Foxp3+) and activated Tconv (Foxp3), before (pre) or after an additional 48 h of culture in the absence of IL-2 (post). Expression levels of genes indicated was assessed by qPCR. Data shown are the mean±S.E. from five independent experiments with statistical analysis performed using standard paired t-test (*P<0.05, **P<0.01, ***P<0.005). (c) Intracellular Bcl-2 of freshly sorted iTregs (Foxp3+) and activated Tconv (Foxp3) before (pre) or after an additional 48 h of culture in the absence of IL-2 (post). Data represent two independent experiments

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