Figure 3

From: CD99 ligation upregulates HSP70 on acute lymphoblastic leukemia cells and concomitantly increases NK cytotoxicity

Figure 3

CD99 ligation enhances NK92-mediated cytotoxicity against ALL but not ET cells. Cytotoxicity assays with ALL and ET cells (4–5 for each cell line) were performed with NK92 cells as effectors. Annexin V and 7AAD were used to detect lysed targeted cells. CD99 induced HSP70 (insets in the graphics) and in parallel increased NK92 cytotoxicity against Jurkat (a) and Reh (b) (3 h of co-incubation) cells. (c) Cytotoxicity of NK92 cells against primary BCP-ALL (three independent ETV6/RUNX1-positive cases are shown)