Figure 2 | Cell Death & Disease

Figure 2

From: Drosophila happyhour modulates JNK-dependent apoptosis

Figure 2

hppy promotes caspase-dependent apoptosis. (a) Ectopic expression of hppy causes cell death in Drosophila wing discs. The area of en-Gal4-driven gene expression is marked with GFP fluorescence (top). The region of cells with nuclear chromatin condensation, as revealed by Hoechst staining, is indicated with the dashed line (middle). TUNEL-positive cells colocalise with nuclear DNA condensation (bottom). (b) Ectopic expression of hppy in the posterior compartment of the wing causes a defect in the wing structure. The black line denotes the boundary between the anterior and posterior compartments of the adult wing. (c) hppy induces caspase activation. The area of en-Gal4-driven gene expression is marked with GFP fluorescence (top). Wing discs from larvae with the indicated genotypes were stained with an anti-active caspase-3 antibody (bottom). The scale bars represent 20 μm

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