Figure 1 | Cell Death & Differentiation

Figure 1

From: Powering stem cell decisions with ubiquitin

Figure 1

Upper panel: in stem cells, the E3 ubiquitin ligase SCFFBXO15 recognizes acetylated KBP, thereby inducing its ubiquitylation and proteasomal degradation. This limits mitochondrial biogenesis. Lower panel: in differentiating cells, acetylation of KBP and expression of FBXO15 are reduced, resulting in KBP stabilization and enhanced mitochondrial biogenesis

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