Figure 4 | Cell Death & Differentiation

Figure 4

From: The late stages of autophagy: how does the end begin?

Figure 4

A model of dynamics of Atg16L complex and LC3s. The dynamics of the Atg16L complex and LC3s during autophagosome formation. Star: Atg16L complex. White circle: LC3 form-I. White circle associated with black patch: LC3 form-II. On the basis of a report that Atg16L complex determines the site of the LC3 lipidation reaction, it is postulated that the reaction occurs on the outer surface of forming autophagosomes. LC3s may function at the verge of the membrane in closure. The detachment of LC3/Atg8 from the inner autophagosomal membrane has been clearly shown only in yeast

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