Figure 3 | Cell Death & Differentiation

Figure 3

From: The late stages of autophagy: how does the end begin?

Figure 3

Hypothetical model of LC3-mediated autophagosome closure. (a) The stalk-pore model of HA mediated viral-endosomal membrane fusion. The white rectangle represents HA. HA is inserted into both the viral and endosomal membranes, and by the force generated from HA bending, the membranes undergo hemifusion. Then, a stalk is generated and becomes a membrane pore. Widening of the pore leads to membrane fusion. (b) A hypothetical model of LC3-mediated autophagosome closure. The white rectangle represents LC3, and the events are depicted from bottom to top. As a result of extension, the leading edge of the isolation membrane converges to a hole narrow enough that LC3 molecules meet. LC3 catalyzes the mixture of the lipids in the cytoplasmic leaflet of the hole, and a stalk forms. The stalk may be disintegrated spontaneously to complete autophagosome formation

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