Table 2 Genes differentially expressed in brain tissue from HtrA2 KO mice selected by GSEA

From: Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

     Gene set Gene set Gene set
Genebank Gene symbol Gene name KO/WT MEF rotenone Neurotoxin treatment (ISR) ATF4 target genes
NM_007837 CHOP C/EBP homologous protein 3.62 Y Y Y
BB758291 Shmt2 Serine hydroxymethyl transferase 2 (mitochondrial) 3.03 Y N N
BG076333 Mthfd2 Methylenetetrahydrofolate dehydrogenase (NAD+ dependent) 2.69 Y N Y
BC025169 Chac1 ChaC, cation transport regulator-like 1 (E. coli) 2.29 Y N N
AF378760 Plxdc1 Plexin domain containing 1 2.16 Y N N
NM_013525 Gas5 Growth arrest specific 5 2.15 N Y N
BB774473 Stc2 Stanniocalcin 2 2.13 Y N Y
AF173681 Txnip Thioredoxin interacting protein 2.07 Y N N
BB550183 Dbp D site albumin promoter binding protein 1.97 Y N N
AI317241 Cars Cysteinyl-tRNA synthetase 1.93 N Y N
AV216412 Eif4ebp1 Eukaryotic translation initiation factor 4E-binding protein 1 1.92 Y Y Y
NM_022331 Herp Homocysteine-, ER stress-inducible, ubiquitin-like domain member 1 1.90 N N Y
BC026131 Slc7a5 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 1.87 Y Y Y
BC008612 Sars Seryl-aminoacyl-tRNA synthetase 1.86 Y N Y
AV212753 Asns Asparagine synthetase 1.85 Y N Y
NM_133900 Psph Phosphoserine phosphatase 1.75 Y N Y
BC026611 Aars Alanyl-tRNA synthetase 1.74 N N Y
NM_011150 Lgals3bp Lectin, galactoside-binding, soluble, 3 binding protein 1.71 N N Y
BI143942 Sord Sorbitol dehydrogenase 1.68 Y N N
BC010318 Pck2 Phosphoenolpyruvate carboxykinase 2 (mitochondrial) 1.67 Y N Y
BI465857 Klf5 Kruppel-like factor 5 1.67 Y N N
NM_007625 Cbx4 Chromobox homolog 4 (Drosophila Pc class) 1.66 Y N N
AI266964 2610042O14Rik RIKEN cDNA 2610042O14 gene 1.64 Y N N
BE956863 Pvt1 Plasmacytoma variant translocation 1 1.59 Y N N
NM_026230 H2afy3 H2A histone family, member Y3 1.59 Y N N
NM_134151 Yars Tyrosyl-tRNA synthetase 1.57 N N Y
BG065238 Phf17 PHD finger protein 17 1.56 Y N N
D11089 Hspa9a/Grp75 Heat-shock protein 9A 1.56 N Y Y
NM_134137 Lars Leucyl-tRNA synthetase 1.54 N N Y
AK013880 Nars Asparaginyl-tRNA synthetase 1.52 N N Y
BB277461 Slc1a4 Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 1.49 Y Y N
BC012955 Trib3 Tribbles homolog 3 (Drosophila) 1.49 Y N Y
AK018158 Stx17 Syntaxin 17 1.49 Y N N
AA985754 Eif2s2 Eukaryotic translation initiation factor 2, subunit 2 (beta) 1.47 Y N N
BB238025 Zxdc ZXD family zinc finger C 1.46 Y N N
AW539046 Sfrs6 Splicing factor, arginine/serine-rich 6 1.44 Y N N
BC019946 Atf3 Activating transcription factor 3 1.44 Y Y Y
AK011528 Sfrs2 Splicing factor, arginine/serine-rich 2 (SC-35) 1.42 Y N N
NM_008135 Slc6a9/Glyt1 Solute carrier family 6 (neurotransmitter transporter, glycine), member 9 1.40 N Y Y
U25708 Slc3a2 Solute carrier family 3 (activators of dibasic and neutral amino-acid transport), member 2 1.39 Y N Y
NM_025875 Rbm8a RNA-binding motif protein 8a 1.39 Y N N
NM_008654 Myd116/Gadd34 Myeloid differentiation primary response gene 116 1.39 N Y N
AK004695 Vps11 Vacuolar protein sorting 11 (yeast) 1.37 Y N N
NM_018772 Bri3 Brain protein I3 1.37 Y N N
BC005518 Rhbdd1 Rhomboid domain containing 1 1.36 Y N N
AI506310 Brd2 Bromodomain containing 2 1.35 Y N N
NM_010072 Dpm1 Dolichol-phosphate (beta-D) mannosyltransferase 1 1.34 Y N N
AK011367 Btf3l4 Basic transcription factor 3-like 4 1.32 N N Y
AK007667 1810031K17Rik RIKEN cDNA 1810031K17 gene 1.29 Y N N
AY015061 Lats2 Large tumor suppressor 2 1.28 Y N N
BI408204 Ubap2 l Ubiquitin-associated protein 2-like 0.78 Y N N
AK018482 Fbxo9 f-box only protein 9 0.75 Y N N
BQ174163 Tmem167 Transmembrane protein 167 0.73 Y N N
BG069656 E430034L04Rik RIKEN cDNA E430034L04 gene 0.73 Y N N
NM_130450 Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast) 0.73 Y N N
AV012790 Sfrs12 Splicing factor, arginine/serine-rich 12 0.73 Y N N
BC025600 Tmem119 Transmembrane protein 119 0.72 Y N N
M25487 Hist1h2bp Histone 1, H2bp 0.72 Y N N
AB072498 Apex2 Apurinic/apyrimidinic endonuclease 2 0.70 Y N N
U31625 Brca1 Breast cancer 1 0.70 N N Y
BC005547 Tubb2c Tubulin, beta 2c 0.69 Y N N
BC004738 Dhcr24 24-Dehydrocholesterol reductase 0.69 Y N N
BB354684 Trib2 Tribbles homolog 2 (Drosophila) 0.68 Y N N
AK004285 1110057K04Rik RIKEN cDNA 1110057K04 gene 0.68 Y N N
AW491660 Tuba4 Tubulin, alpha 4 0.67 Y N N
NM_007856 Dhcr7 7-Dehydrocholesterol reductase 0.67 Y N N
BC023136 Sbno1 sno, strawberry notch homolog 1 (Drosophila) 0.67 Y N N
NM_009062 Rgs4 Regulator of G-protein signaling 4 0.66 Y N N
NM_009722 Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.65 Y N N
BF147037 Sfrs1 Splicing factor, arginine/serine-rich 1 (ASF/SF2) 0.65 Y N N
AI467599 Crem cAMP responsive element modulator 0.64 Y N N
BB049138 Pvr Poliovirus receptor 0.63 Y N N
NM_007631 Ccnd1 Cyclin D1 0.62 Y N N
BE648432 Arpp19 cAMP-regulated phosphoprotein 19 0.61 Y N N
AW555393 Mest Mesoderm-specific transcript 0.59 Y N N
BG060909 Scd1 Stearoyl-Coenzyme A desaturase 1 0.59 Y N N
BC010816 Lims2 LIM and senescent cell antigen-like domains 2 0.57 Y N N
NM_009270 Sqle Squalene epoxidase 0.56 Y N N
M12573 Hspa1b/Hsp70 Heat-shock protein 1B 0.54 Y N N
NM_020010 Cyp51 Cytochrome P450, family 51 0.53 Y N N
BB705380 Hmgcs1 3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 1 0.52 Y N N
NM_019469 Hist2h3c1 Histone 2, H3c1 0.52 Y N N
NM_010444 Nr4a1/Nurr77 Nuclear receptor subfamily 4, group A, member 1 0.50 Y N N
AK014587 Stard4 StAR-related lipid transfer (START) domain containing 4 0.49 Y N N
AF425607 Ldlr Low-density lipoprotein receptor 0.48 Y N N
BC004801 Idi1 Isopentenyl-diphosphate delta isomerase 0.37 Y N N
NM_018790 Arc Activity regulated cytoskeletal-associated protein 0.31 Y N N
  1. List of genes compiled from the overlaps between genes differentially expressed in WT and HtrA2 KO cortex and the gene sets used for GSEA. For gene sets, see the legend of Table 1. The KO/WT column shows the fold change in HtrA2 KO cortex compared with WT