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Second-degree relative donors for T-replete haploidentical allogeneic stem cell transplantation with high-dose post-transplant cyclophosphamide: toward crossing the major HLA barrier

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References

  1. Luznik L, O’Donnell PV, Fuchs EJ . Post-transplantation cyclophosphamide for tolerance induction in HLA-haploidentical bone marrow transplantation. Semin Oncol 2012; 39: 683–693.

    Article  CAS  PubMed  Google Scholar 

  2. Munchel A, Kesserwan C, Symons HJ, Luznik L, Kasamon YL, Jones RJ et al. Nonmyeloablative, HLA-haploidentical bone marrow transplantation with high dose, post-transplantation cyclophosphamide. Pediatr Rep 2011; 3 (Suppl 2): e15.

    PubMed  PubMed Central  Google Scholar 

  3. Zhang YY, Liu DH, Liu KY, Xu LP, Chen H, Han W et al. HLA-haploidentical hematopoietic SCT from collateral related donors without in vitro T-cell depletion for hematological malignancies. Bone Marrow Transplant 2014; 49: 496–501.

    Article  PubMed  Google Scholar 

  4. Chang YJ, Luznik L, Fuchs EJ, Huang XJ . How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation? J Hematol Oncol 2016; 9: 35.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Tiercy JM . How to select the best available related or unrelated donor of hematopoietic stem cells? Haematologica 2016; 101: 680–687.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Kasamon YL, Ambinder RF, Fuchs EJ, Zahurak M, Rosner GL, Bolaños-Meade J et al. Prospective study of nonmyeloablative, HLA-mismatched unrelated BMT with high-dose posttransplantation cyclophosphamide. Blood Adv 2017; 1: 288–292.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Kawai T, Sachs DH, Sykes M, Cosimi AB . Immune tolerance network. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2013; 368: 1850–1852.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

Author contributions

AG and PC wrote the paper. PC supervised the entire work. TGu, PP, YL, VD, BM, MCB, TGa, CT, NB, SL and PM critically revised the manuscript. All authors approved the final manuscript.

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Correspondence to P Chevallier.

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Garnier, A., Guillaume, T., Peterlin, P. et al. Second-degree relative donors for T-replete haploidentical allogeneic stem cell transplantation with high-dose post-transplant cyclophosphamide: toward crossing the major HLA barrier. Bone Marrow Transplant 52, 1063–1064 (2017). https://doi.org/10.1038/bmt.2017.60

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