This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Prognostic impact of the AML ELN2022 risk classification in patients undergoing allogeneic stem cell transplantation
Blood Cancer Journal Open Access 19 December 2022
-
ELN risk stratification and outcomes in secondary and therapy-related AML patients consolidated with allogeneic stem cell transplantation
Bone Marrow Transplantation Open Access 19 November 2020
-
Allogeneic stem cell transplantation mitigates the adverse prognostic impact of high diagnostic BAALC and MN1 expression in AML
Annals of Hematology Open Access 29 August 2020
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Döhner H, Estey EH, Amadori S, Appelbaum FR, Büchner T, Burnett AK et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010; 115: 453–474.
Röllig C, Bornhäuser M, Thiede C, Taube F, Kramer M, Mohr B et al. Long-term prognosis of acute myeloid leukemia according to the new genetic risk classification of the European LeukemiaNet recommendations: evaluation of the proposed reporting system. J Clin Oncol 2011; 29: 2758–2765.
Mrózek K, Marcucci G, Nicolet D, Maharry KS, Becker H, Whitmann SP et al. Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia. J Clin Oncol 2012; 30: 4515–4523.
Alpermann T, Kern W, Schnittger S, Schmidt C, Kreuzer KA, Serve H et al. Evaluation of the proposed reporting system of the European LeukemiaNet and recommendations for prognosis of acute myeloid leukemia. Leuk Res 2013; 37: 197–200.
Schlenk RF, Döhner K, Mack S, Stoppel M, Király F, Götze K et al. Prospective evaluation of allogeneic hematopoietic stem-cell transplantation from matched related and matched unrelated donors in younger adults with high-risk acute myeloid leukemia: German-Austrian trial AMLHD98A. J Clin Oncol 2010; 28: 4642–4648.
Cornelissen JJ, Gratwohl A, Schlenk RF, Sierra J, Bornhäuser M, Juliusson G et al. The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach. Nat Rev Clin Oncol 2012; 9: 579–590.
Oran B, Jimenez AM, De Lima M, Popat UR, Bassett R, Andersson BS et al. Age and modified European LeukemiaNet classification to predict transplant outcomes: an integrated approach for acute myelogenous leukemia patients undergoing allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2015; 21: 1405–1412.
Thiede C, Steudel C, Mohr B, Schaich M, Schäkel U, Platzbecker U et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood 2002; 99: 4326–4335.
Thiede C, Koch S, Creutzig E, Steudel C, Illmer T, Schaich M et al. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood 2006; 107: 4011–4020.
Hegenbart U, Niederwieser D, Sandmaier BM, Maris MB, Shizuru JA, Greinix H et al. Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors. J Clin Oncol 2006; 24: 444–453.
Gyurkocza B, Storb R, Storer BE, Chauncey TR, Lange T, Shizuru JA et al. Nonmyeloablative allogeneic hematopoietic cell transplantation in patients with acute myeloid leukemia. J Clin Oncol 2010; 28: 2859–2867.
Whitman SP, Maharry K, Radmacher MD, Becker H, Mrózek K, Margeson D et al. FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. Blood 2010; 116: 3622–3626.
Schlenk RF, Kayser S, Bullinger L, Kobbe G, Casper J, Ringhoffer M et al. Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation. Blood 2014; 124: 3441–3449.
Breems DA, Van Putten WL, De Greef GE, Van Zelderen-Bhola SL, Gerssen-Schoorl KB, Mellink CH et al. Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol 2008; 26: 4791–4797.
Middeke JM, Beelen D, Stadler M, Goehring G, Schlegelberger B, Baurmannet H et al. Outcome of high-risk acute myeloid leukemia after allogeneic hematopoietic cell transplantation: negative impact of abnl(17p) and -5/5q-. Blood 2012; 120: 2521–2528.
Acknowledgements
MB was supported by an intramural scholarship of the medical faculty of the University of Leipzig (#990101-089). We thank Janet Bogardt, Annette Jilo and Dagmar Cron for assistance with collecting the AML patient samples. We thank Sabine Leiblein, Christel Müller, Evelin Hennig, Daniela Bretschneider, Christine Günther, Martina Pleß, Ulrike Bergmann and Rainer Krahl who helped to determine the cytogenetics and immunological analysis. Ines Kovacs, Scarlett Schwabe and Christine Günther assisted with material processing. Presented partly in abstract form at the 41st annual meeting of the European Society for Blood and Marrow Transplantation, Istanbul, Turkey, 24 March 2015; and at the ESH-EBMT Training Course on Hematopoietic Stem Cell Transplantation, Budapest, Hungary, 11–14 May 2016.
Author contributions
MB and SS designed and performed the experiments. KS performed the experiments. MB, MJ and SS analyzed and interpreted the data. TL, MC, GB, VV, WP and G-NF provided administrative and technical support. MB and SS wrote, and all authors reviewed and approved the manuscript. DN and SS supervised the study.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies this paper on Bone Marrow Transplantation website
Rights and permissions
About this article
Cite this article
Bill, M., Jentzsch, M., Grimm, J. et al. Prognostic impact of the European LeukemiaNet standardized reporting system in older AML patients receiving stem cell transplantation after non-myeloablative conditioning. Bone Marrow Transplant 52, 932–935 (2017). https://doi.org/10.1038/bmt.2017.42
Published:
Issue Date:
DOI: https://doi.org/10.1038/bmt.2017.42
This article is cited by
-
Prognostic impact of the AML ELN2022 risk classification in patients undergoing allogeneic stem cell transplantation
Blood Cancer Journal (2022)
-
ELN risk stratification and outcomes in secondary and therapy-related AML patients consolidated with allogeneic stem cell transplantation
Bone Marrow Transplantation (2021)
-
Allogeneic stem cell transplantation mitigates the adverse prognostic impact of high diagnostic BAALC and MN1 expression in AML
Annals of Hematology (2020)
-
Clinical impact of clonal hematopoiesis in acute myeloid leukemia patients receiving allogeneic transplantation
Bone Marrow Transplantation (2019)
-
Prognostic relevance of DNMT3A R882 mutations in AML patients undergoing non-myeloablative conditioning hematopoietic stem cell transplantation
Bone Marrow Transplantation (2018)