Table 3 Regression models for one-year NRM and OS, based on day 28 follistatin levels

From: Donor and recipient plasma follistatin levels are associated with acute GvHD in Blood and Marrow Transplant Clinical Trials Network 0402

Factor   NRM OS
  N 1-Year estimate (95% CI) p RR (95% CI) P 1-Year estimate (95% CI) P RR (95% CI) P
Follistatin    <0.01     <0.01   
1088 189 8% (4–12%)   1.0   81% (75–86%)   1.0  
 >1088 32 31% (15–47%)   4.3 (1.9–9.9) <0.01 56% (38–71%)   2.8 (1.5–5.2) <0.01
Recipient Age    0.02     0.05   
 <35 53 2% (0–6%)   1.0   89% (81–97%)   1.0  
 35–49 120 13% (7–18%)   6.2 (0.9–43.8) 0.07 77% (70–84%)   2.0 (0.8–5.0) 0.11
50 48 19% (8–30%)   10.5 (1.4–76.5) 0.02 69% (56–82%)   3.1 (1.2–8.0) 0.02
  1. Abbreviations: NRM=non-relapse mortality; OS=overall survival; RR=relative risk.
  2. Other factors considered in model: GvHD prophylaxis, conditioning, recipient sex, recipient/donor sex match, disease, CMV serostatus, year of transplant and time-dependent onset of GvHD.