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Higher rates of relapse in maternal recipients of haploidentical hematopoietic stem cell transplantation from adult offspring donors for AML and myelodysplastic syndrome

Bone Marrow Transplantation volume 52, pages 1465–1467 (2017)Cite this article

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Haploidentical hematopoietic stem cell transplantation (HI HSCT) has increased in frequency over the past decade due to advances in the safety of the procedure and a decreasing pool of HLA- matched related donors.1 Most patients have more than one haploidentical donor option, allowing for characteristics other than HLA matching, such as familial relationships, to be considered in donor selection.

During pregnancy, bidirectional trafficking of cells at the fetal–maternal interface results in the establishment of maternal microchimerism in the fetus and fetal microchimerism in the mother.2 Major and minor histocompatibility antigens expressed by these cells induce tolerogenic responses mediated in part by regulatory T-cells. Maternal microchimerism, and tolerance to non-inherited maternal antigens (NIMA), persists into adulthood in many offspring.3, 4, 5

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Authors and Affiliations

  1. Department of Medical Oncology, Kimmel Cancer Center, Philadelphia, PA, USA

    P R Geethakumari, S O Alpdogan, M Carabasi, J Filicko-O’Hara, S Gaballa, M Kasner, T Klumpp, U Martinez-Outschoorn, N Palmisiano, J L Wagner, P Porcu, N Flomenberg & D Grosso

  2. Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA

    B Leiby

  3. Department of Epidemiology and Biostatistics, Temple University, Philadelphia, PA, USA

    R Nair

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  1. P R Geethakumari
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  14. N Flomenberg
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  15. D Grosso
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Corresponding author

Correspondence to D Grosso.

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Geethakumari, P., Leiby, B., Nair, R. et al. Higher rates of relapse in maternal recipients of haploidentical hematopoietic stem cell transplantation from adult offspring donors for AML and myelodysplastic syndrome. Bone Marrow Transplant 52, 1465–1467 (2017). https://doi.org/10.1038/bmt.2017.159

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