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Chronic Leukemia

Long-term survival of patients with CLL after allogeneic transplantation: a report from the European Society for Blood and Marrow Transplantation

Bone Marrow Transplantation volume 52, pages 372–380 (2017)Cite this article

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Abstract

Even with the availability of targeted drugs, allogeneic hematopoietic cell transplantation (allo-HCT) is the only therapy with curative potential for patients with CLL. Cure can be assessed by comparing long-term survival of patients to the matched general population. Using data from 2589 patients who received allo-HCT between 2000 and 2010, we used landmark analyses and methods from relative survival analysis to calculate excess mortality compared with an age-, sex- and calendar year-matched general population. Estimated event-free survival, overall survival and non-relapse mortality (NRM) 10 years after allo-HCT were 28% (95% confidence interval (CI), 25–31), 35% (95% CI, 32–38) and 40% (95% CI, 37–42), respectively. Patients who passed the 5-year landmark event-free survival (N=394) had a 79% probability (95% CI, 73–85) of surviving the subsequent 5 years without an event. Relapse and NRM contributed equally to treatment failure. Five-year mortality for 45- and 65-year-old reference patients who were event-free at the 5-year landmark was 8% and 47% compared with 3% and 14% in the matched general population, respectively. The prospect of long-term disease-free survival remains an argument to consider allo-HCT for young patients with high-risk CLL, and programs to understand and prevent late causes of failure for long-term survivors are warranted, especially for older patients.

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References

  1. Stilgenbauer S, Eichhorst B, Schetelig J, Coutre S, Seymour JF, Munir T et al. Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study. Lancet Oncol 2016; 17: 768–778.

    Article  CAS  Google Scholar 

  2. Byrd JC, Jones JJ, Woyach JA, Johnson AJ, Flynn JM . Entering the era of targeted therapy for chronic lymphocytic leukemia: impact on the practicing clinician. J Clin Oncol 2014; 32: 3039–3047.

    Article  CAS  Google Scholar 

  3. Byrd JC, Furman RR, Coutre SE, Burger JA, Blum KA, Coleman M et al. Three-year follow-up of treatment-naive and previously treated patients with CLL and SLL receiving single-agent ibrutinib. Blood 2015; 125: 2497–2506.

    Article  CAS  Google Scholar 

  4. Schetelig J, Thiede C, Bornhauser M, Schwerdtfeger R, Kiehl M, Beyer J et al. Evidence of a graft-versus-leukemia effect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation: the Cooperative German Transplant Study Group. J Clin Oncol 2003; 21: 2747–2753.

    Article  CAS  Google Scholar 

  5. Ritgen M, Stilgenbauer S, Von Neuhoff N, Humpe A, Bruggemann M, Pott C et al. Graft-versus-leukemia activity may overcome therapeutic resistance of chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy chain gene status: implications of minimal residual disease measurement with quantitative PCR. Blood 2004; 104: 2600–2602.

    Article  CAS  Google Scholar 

  6. Sorror ML, Storer BE, Sandmaier BM, Maris M, Shizuru J, Maziarz R et al. Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. J Clin Oncol 2008; 26: 4912–4920.

    Article  Google Scholar 

  7. Dreger P, Dohner H, Ritgen M, Bottcher S, Busch R, Dietrich S et al. Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood 2010; 116: 2438–2447.

    Article  CAS  Google Scholar 

  8. Brown JR, Kim HT, Armand P, Cutler C, Fisher DC, Ho V et al. Long-term follow-up of reduced-intensity allogeneic stem cell transplantation for chronic lymphocytic leukemia: prognostic model to predict outcome. Leukemia 2013; 27: 362–369.

    Article  CAS  Google Scholar 

  9. Dreger P, Schetelig J, Andersen N, Corradini P, van Gelder M, Gribben J et al. Managing high-risk CLL during transition to a new treatment era: stem cell transplantation or novel agents? Blood 2014; 124: 3841–3849.

    Article  CAS  Google Scholar 

  10. Jain P, Keating M, Wierda W, Estrov Z, Ferrajoli A, Jain N et al. Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinib. Blood 2015; 125: 2062–2067.

    Article  CAS  Google Scholar 

  11. Mato A, Nabhan C, Barr PM, Ujjani CS, Hill BT, Lamanna N et al. Favorable outcomes in CLL pts with alternate kinase inhibitors following ibrutinib or idelalisib discontinuation: results from a large multi-center study. Blood 2015; 126: 719.

    Article  Google Scholar 

  12. Jones J, Mato AR, Coutre S, Wierda W, Choi MY, Davids MS et al. Preliminary results of a phase 2, open-label study of venetoclax (ABT-199/GDC-0199) monotherapy in patients with chronic lymphocytic leukemia relapsed after or refractory to ibrutinib or idelalisib therapy. Blood 2015; 126: 715.

    Article  Google Scholar 

  13. Byrd JC, Wierda W, Jones J, O'Brien S, Brown JR, Schuh A et al. The Bruton tyrosine kinase (Btk) inhibitor ACP-196: marked activity in relapsed/refractory CLL with a favorable safety profile. Blood 2015; 126: 831.

    Article  Google Scholar 

  14. Iacobelli S . Suggestions on the use of statistical methodologies in studies of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 2013; 48 (Suppl 1): S1–37.

    Article  Google Scholar 

  15. Stare J, Pohar M, Henderson R . Goodness of fit of relative survival models. Stat Med 2005; 24: 3911–3925.

    Article  Google Scholar 

  16. Pohar M, Stare J . Relative survival analysis in R. Comput Methods Programs Biomed 2006; 81: 272–278.

    Article  Google Scholar 

  17. Nicolaie MA, van Houwelingen HC, Putter H . Vertical modeling: a pattern mixture approach for competing risks modeling. Stat Med 2010; 29: 1190–1205.

    CAS  PubMed  Google Scholar 

  18. Sobecks RM, Leis JF, Gale RP, Ahn KW, Zhu X, Sabloff M et al. Outcomes of human leukocyte antigen-matched sibling donor hematopoietic cell transplantation in chronic lymphocytic leukemia: myeloablative versus reduced-intensity conditioning regimens. Biol Blood Marrow Transplant 2014; 20: 1390–1398.

    Article  CAS  Google Scholar 

  19. Sabloff M, Sobecks RM, Ahn KW, Zhu X, de Lima M, Brown JR et al. Does total body irradiation conditioning improve outcomes of myeloablative human leukocyte antigen-identical sibling transplantations for chronic lymphocytic leukemia? Biol Blood Marrow Transplant 2014; 20: 421–424.

    Article  Google Scholar 

  20. Martin PJ, Counts GW Jr., Appelbaum FR, Lee SJ, Sanders JE, Deeg HJ et al. Life expectancy in patients surviving more than 5 years after hematopoietic cell transplantation. J Clin Oncol 2010; 28: 1011–1016.

    Article  Google Scholar 

  21. Goldman JM, Majhail NS, Klein JP, Wang Z, Sobocinski KA, Arora M et al. Relapse and late mortality in 5-year survivors of myeloablative allogeneic hematopoietic cell transplantation for chronic myeloid leukemia in first chronic phase. J Clin Oncol 2010; 28: 1888–1895.

    Article  Google Scholar 

  22. Wingard JR, Majhail NS, Brazauskas R, Wang Z, Sobocinski KA, Jacobsohn D et al. Long-term survival and late deaths after allogeneic hematopoietic cell transplantation. J Clin Oncol 2011; 29: 2230–2239.

    Article  Google Scholar 

  23. Bhatia S, Francisco L, Carter A, Sun CL, Baker KS, Gurney JG et al. Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study. Blood 2007; 110: 3784–3792.

    Article  CAS  Google Scholar 

  24. Sorror ML, Maris MB, Sandmaier BM, Storer BE, Stuart MJ, Hegenbart U et al. Hematopoietic cell transplantation after nonmyeloablative conditioning for advanced chronic lymphocytic leukemia. J Clin Oncol 2005; 23: 3819–3829.

    Article  Google Scholar 

  25. Chow EJ, Wong K, Lee SJ, Cushing-Haugen KL, Flowers ME, Friedman DL et al. Late cardiovascular complications after hematopoietic cell transplantation. Biol Blood Marrow Transplant 2014; 20: 794–800.

    Article  Google Scholar 

  26. Pophali PA, Klotz JK, Ito S, Jain NA, Koklanaris E, Le RQ et al. Male survivors of allogeneic hematopoietic stem cell transplantation have a long term persisting risk of cardiovascular events. Exp Hematol 2014; 42: 83–89.

    Article  Google Scholar 

  27. Sun CL, Kawashima T, Leisenring W, Robison LL, Baker KS, Weisdorf DJ et al. Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study. Blood 2010; 116: 3129–3139.

    Article  CAS  Google Scholar 

  28. Hahn M, Bottcher S, Dietrich S, Hegenbart U, Rieger M, Stadtherr P et al. Allogeneic hematopoietic stem cell transplantation for poor-risk CLL: dissecting immune-modulating strategies for disease eradication and treatment of relapse. Bone Marrow Transplant 2015; 50: 1279–1285.

    Article  CAS  Google Scholar 

  29. Syrjala KL, Martin PJ, Lee SJ . Delivering care to long-term adult survivors of hematopoietic cell transplantation. J Clin Oncol 2012; 30: 3746–3751.

    Article  Google Scholar 

  30. Majhail NS, Rizzo JD, Lee SJ, Aljurf M, Atsuta Y, Bonfim C et al. Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation. Bone Marrow Transplant 2012; 47: 337–341.

    Article  CAS  Google Scholar 

  31. Bhatia S . Caring for the long-term survivor after allogeneic stem cell transplantation. Hematology Am Soc Hematol Educ Program 2014; 2014: 495–503.

    Article  Google Scholar 

  32. Dreger P, Brand R, Milligan D, Corradini P, Finke J, Lambertenghi Deliliers G et al. Reduced-intensity conditioning lowers treatment-related mortality of allogeneic stem cell transplantation for chronic lymphocytic leukemia: a population-matched analysis. Leukemia 2005; 19: 1029–1033.

    Article  CAS  Google Scholar 

  33. Landau DA, Tausch E, Taylor-Weiner AN, Stewart C, Reiter JG, Bahlo J et al. Mutations driving CLL and their evolution in progression and relapse. Nature 2015; 526: 525–530.

    Article  CAS  Google Scholar 

  34. Rozovski U, Benjamini O, Jain P, Thompson PA, Wierda WG, O'Brien S et al. Outcomes of patients with chronic lymphocytic leukemia and Richter's transformation after transplantation failure. J Clin Oncol 2015; 33: 1557–1563.

    Article  Google Scholar 

  35. Montserrat E, Dreger P . Hope for high-risk chronic lymphocytic leukemia relapsing after allogeneic stem-cell transplantation. J Clin Oncol 2015; 33: 1527–1529.

    Article  CAS  Google Scholar 

  36. Link CS, Heidenreich F, Rücker-Braun E, Schmiedgen M, Reinhardt J, Oelschlägel U et al. Durable responses to ibrutinib in patients with relapsed CLL after allogeneic stem cell transplantation. Bone Marrow Transplant 2016; 51: 793–798.

    Article  CAS  Google Scholar 

  37. Coutre S, O'Brien S, Byrd JC, Hillmen P, Brown JR, Dyer MJ et al. Safety and efficacy of ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma who have undergone prior allogeneic stem cell transplant. Blood 2014; 124: 4697.

    Google Scholar 

Download references

Acknowledgements

We thank Maja Pohar Perme (Institute for Biostatistics and Medical Informatics, University of Ljubljana, Ljubljana, Slovenia) for help with the software. Further, we are very grateful to Emili Montserrat who gave substantial input and critically revised the manuscript.

Author information

Author notes

  1. M van Gelder, L C de Wreede, M Bornhäuser, D Niederwieser, M Karas, N S Anderson, M Gramatzki, P Dreger, M Michallet, E Petersen, D Bunjes, M Potter, D Beelen, J J Cornelissen, I Yakoub-Agha, N H Russell, J Finke, H Schoemans, A Vitek, Á Urbano-Ispízua, D Blaise, L Volin, P Chevallier, D Caballero, H Putter, A van Biezen, A Henseler, S Schönland, N Kröger and J Schetelig: M van Gelder and L C de Wreede: These authors contributed equally to this work.

  2. The Chronic Malignancy Working Party members are listed above references.

Authors and Affiliations

  1. Department of Internal Medicine/Hematology, University Hospital Maastricht, Maastricht, The Netherlands

    M van Gelder

  2. DKMS, gemeinnützige GmbH, Tübingen, Germany

    L C de Wreede & J Schetelig

  3. Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands

    L C de Wreede, H Putter, A van Biezen & A Henseler

  4. Medizinische Klinik und Poliklinik I, Universitätsklinikum Dresden, Technische Universität Dresden, Dresden, Germany

    M Bornhäuser & J Schetelig

  5. Division of Hematology, Oncology and Hemostasiology, University Hospital Leipzig, Leipzig, Germany

    D Niederwieser

  6. Department of Hematology/Oncology, Charles University Hospital, Pilsen, Czech Republic

    M Karas

  7. Department of Hematology, BMT Unit, Rigshospitalet, Copenhagen, Denmark

    N S Anderson

  8. Division of Stem Cell Transplantation and Immunotherapy, University Hospital Schleswig-Holstein, Kiel, Germany

    M Gramatzki

  9. Medizinische Klinik und Poliklinik V, University of Heidelberg, Heidelberg, Germany

    P Dreger & S Schönland

  10. Center Hospitalier Lyon-Sud – Hématologie, Lyon, France

    M Michallet

  11. Department of Haematology, University Medical Center, Utrecht, The Netherlands

    E Petersen

  12. Klinik fuer Innere Medizin III, Universitätsklinikum Ulm, Ulm, Germany

    D Bunjes

  13. Leukaemia Myeloma Units, Royal Marsden Hospital, London, Surrey, UK

    M Potter

  14. Department of Bone Marrow Transplantation, University Hospital, Essen, Germany

    D Beelen

  15. Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

    J J Cornelissen

  16. Hôpital HURIEZ, UAM allo-CSH, CHRU, Lille, France

    I Yakoub-Agha

  17. Nottingham City Hospital, Nottingham, UK

    N H Russell

  18. Department of Medicine-Hematology, Oncology, University of Freiburg, Freiburg, Germany

    J Finke

  19. Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium

    H Schoemans

  20. Institute of Hematology and Blood Transfusion, Prague, Czech Republic

    A Vitek

  21. Department of Hematology, Hospital Clinic, Institute of Hematology and Oncology, Barcelona, Spain

    Á Urbano-Ispízua

  22. Programme de Transplantation and Therapie Cellulaire, Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, Marseille, France

    D Blaise

  23. Stem Cell Transplantation Unit, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland

    L Volin

  24. Department D'Hematologie, CHU Nantes, Nantes, France

    P Chevallier

  25. Servicio de Hematología, Hospital Clínico, Salamanca, Spain

    D Caballero

  26. Bone Marrow Transplantation Center, University Hospital Eppendorf, Hamburg, Germany

    N Kröger

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  1. M van Gelder
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  2. L C de Wreede
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  6. N S Anderson
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  9. M Michallet
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  10. E Petersen
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  12. M Potter
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  14. J J Cornelissen
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  21. D Blaise
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  22. L Volin
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  28. S Schönland
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  29. N Kröger
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  30. J Schetelig
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on behalf of the Chronic Malignancy Working Party

Corresponding author

Correspondence to J Schetelig.

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The authors declare no conflict of interest.

Additional information

The Chronic Malignancy Working Party members

Gerhard Ehninger, Universitaetsklinikum Dresden, Dresden, Germany; Dietger Niederwieser, University Hospital Leipzig, Leipzig, Germany; Pavel Jindra, Charles University Hospital, Pilsen, Czech Republic; Henrik Sengeloev, Rigshospitalet, Copenhagen, Denmark; Martin Gramatzki, University Hospital Schleswig-Holstein Kiel Campus, Kiel, Germany; Peter Dreger, University of Heidelberg, Heidelberg, Germany; Eefke Petersen, University Medical Centre, Utrecht, The Netherlands; Donald Bunjes, Universitätsklinikum Ulm, Ulm, Germany; Michael Potter, Royal Marsden Hospital, London, UK; Dietrich Beelen, University Hospital, Essen, Germany; Jan Cornelissen, Erasmus MC-Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands; Ibrahim Yakoub-Agha, Hôpital HURIEZ, Lille, FranceNigel Russell, Nottingham City Hospital, Nottingham, UK; Jürgen Finke, University of Freiburg, Freiburg, Germany; Hélène Schoemans, University Hospital Gasthuisberg, Leuven, Belgium; Antonin Vitek, Institute of Hematology and Blood Transfusion, Prague, Czech Republic; Alvaro Urbano Ispizua, Hospital Clinic, Barcelona, Spain; Didier Blaise, Institut Paoli Calmettes, Marseille, FranceLiisa Volin, HUCH Comprehensive Cancer Center, Helsinki, Finland; Renate Arnold, Charité Universitätsmedizin Berlin, Berlin, Germany; Patrice Chevallier, CHU Nantes, Nantes, France; Dolores Caballero, Hospital Clínico, Salamanca, Spain; Joan Hendrik Veelken, Leiden University Hospital, Leiden, The Netherlands; Ghulam Mufti, GKT School of Medicine, London, UK; Noel Milpied, Hôpital Haut-leveque, Pessac, France; Bruno Benedetto, AOU Citta della Salute e della Scienza di Torino, Torino, Italy; Michel Schaap, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands; Véronique Leblond, Universite Paris IV, Hopital la Pitié-Salpêtrière, Paris, France; Manos Nikolousis, Birmingham Heartlands Hospital, Birmingham, UK; Michael Hallek, University of Cologne, Cologne, Germany; Jakob Passweg, University Hospital, Basel, Switzerland; Per Ljungman, Karolinska University Hospital, Stockholm, Sweden; Tamás Masszi, St István and St Laszlo Hospital, Budapest, Hungary; Matthias Stelljes, University of Münster, Münster, Germany; Paul Browne, St James's Hospital, Dublin, Ireland; Bertram Glass, Asklepios Klinik St Georg, Hamburg, Germany; Carlos Richard Espiga, Hospital U Marqués de Valdecilla, Santander, Spain; Jean Henri Bourhis, Gustave Roussy, Institut de Cancérologie, Villejuif, France; John Gribben, St Bartholomew's and The Royal London NHS Trust, London, UK; Roberto Foa, Univ. 'La Sapienza', Rome, ItalyJorge Sierra, Hospital Santa Creu i Sant Pau, Barcelona, Spain; Jiri Mayer, University Hospital Brno, Brno, Czech Republic; Mauricette Michallet, Centre Hospitalier Lyon Sud, Lyon, France; Kirsty Thomson, University College London Hospital, London, UK; Ellen Meijer, VU University Medical Center, Amsterdam, The Netherlands; Wolfgang Blau, Universitaetsmedizin Berlin, Berlin, Germany; Ernst Holler, University Regensburg, Regensburg, Germany; Andrea Bacigalupo, Ospedale San Martino, Genova, Italy; Francois Guilhot, Hopital La Miletrie, Poitiers, France; Kristina Carlson, University Hospital, Uppsala, Sweden; Pierre Zachée, ZNA, Antwerp, Belgium; Norbert Ifrah, CHRU, Angers, France; José Rafael Cabrera Marín, Hospital Universitario Puerta de Hierro, Madrid, Spain; Gerard Socié, Hopital St Louis, Paris, France; Grant McQuaker, Gartnaval General Hospital, Glasgow, UK; Agostino Cortelezzi, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; Stig Lenhoff, Skanes University Hospital, Lund, Sweden; Johanna Tischer, Klinikum Grosshadern, Munich, Germany; Giuseppe Irrera, Azienda Ospedaliera, Reggio Calabria, Italy; Renato Fanin, Azienda Ospedaliero Universitaria di Udine, Udine, ItalyYves Beguin, CHU Sart-Tilman, Liege, Belgium; Arnon Nagler, Chaim Sheba Medical Center, Tel-Hashomer, Israel; Stephen Mackinnon, Royal Free Hospital and School of Medicine, London, UK; Maija Itälä-Remes, Turku University, Turku, FinlandEric Deconinck, Hopital Jean Minjoz, Besancon, France; Gerald Wulf, Universitätsklinikum Göttingen, Gottingen, Germany; Paolo Corradini, University of Milano, Milano, Italy; Maria Gilleece, Bexley Wing, St James's Institute of Oncology, Leeds, UK; Andy Peniket, Churchill Hospital, Oxford, UK; Arnold Ganser, Hannover Medical School, Hannover, Germany; Gernot Stuhler, Deutsche Klinik für Diagnostik, Wiesbaden, Germany; Edgar Faber, University Hospital, Olomouc, Czech Republic; Michal Komarnicki, Poznan University of Medical Sciences, Poznan, Poland; Lothar Kanz, Universität Tübingen, Tübingen, Germany; Mats Brune, Sahlgrenska University Hospital, Gothenburg, Sweden; Nicolaus Kröger, University Hospital Eppendorf, Hamburg, Germany; Thierry Lamy, Centre Hospitalier Universitaire de Rennes, Rennes, France; Miguel Sanz, Hospital Universitario La Fe, Valencia, Spain; Slawomira Kyrcz-Krzemien, Medical University of Silesia, Katowice, Poland; Kim Orchard, Southampton General Hospital, Southampton, UK; Ann Hunter, Leicester Royal Infirmary, Leicester, UKAnna Sandstedt, University Hospital, Linköping, Sweden; Nathalie Fegueux, CHU Lapeyronie, Montpellier, France; Giuseppe Bandini, Bologna University, S Orsola-Malpighi Hospital, Bologna, Italy; Stephen Robinson, Bristol Royal Hospital for Children, Bristol, UK; Charles Craddock, Queen Elizabeth Hospital, Birmingham, UK; Charles Crawley, Addenbrookes Hospital, Cambridge, UK; Laimonas Griskevicius, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania; Adrian Bloor, Christie NHS Trust Hospital, Manchester, UK; Oumédaly Reman, CHU CAEN, Caen, France; Inken Hilgendorf, Universitätsklinikum Jena, Jena, Germany; Paul Cannell, Fiona Stanley Hospital, Perth Western Australia, Australia; Fabio Ciceri, Ospedale San Raffaele srl, Milano, Italy; Peter Kalhs, Medizinische Universitaet Wien, Vienna, Austria; Simona Sica, Universita Cattolica S Cuore, Rome, Italy; Hildegard Greinix, LKH - University Hospital Graz, Graz, AustriaRosanna Scimè, Ospedale V. Cervello, Palermo, Italy; Dominik Selleslag, AZ Sint-Jan, Brugge, Belgium; William Krüger, Klinik für Innere Medizin C, Greifswald, Germany; Anne Huynh, Institut Universitaire du Cancer Toulouse, Toulouse, France; Herman Einsele, Universitätsklinikum Würzburg, Würzburg, Germany; Jörg Bittenbring, University of Saarland, Homburg, Germany; Attilio Olivieri, Azienda Ospedali Riuniti di Ancona, Ancona, Italy; Olivier Hermine, Hôpital Necker, Paris, FranceTobias Gedde-Dahl, Rikshospitalet, Oslo, Norway; Jozsef Zsiros, Emma Kinderziekenhuis, Amsterdam, The Netherlands; Dennis Guyotat, CHRU St Etienne, Saint Etienne, FranceCatherine Cordonnier, Hôpital Henri Mondor, Creteil, FranceAntonio Campos, Inst. Português de Oncologia do Porto, Porto, PortugalMarco Casini, Hospital San Maurizio, Bolzano, Italy; Giovanni Martinelli, European Institute of Oncology, Milano, ItalyLutz Peter Müller, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany; Gustaaf van Imhoff, University Medical Center Groningen (UMCG), Groningen, The Netherlands; Andreas Neubauer, University Hospital Giessen and Marburg, Marburg, Germany; Bruno Lioure, Nouvel Hopital Civil, Strasbourg, France; Rose-Marie Hamladji, Centre Pierre et Marie Curie, Alger, Algeria; Lucien Noens, University Hospital Gent, Ghent, Belgium; Matthias Theobald, University Medical Center Mainz, Mainz, Germany; Flavia Salvi, H SS. Antonio e Biagio, Alessandria, Italy; Ron Ram, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Xavier Poiré, Cliniques Universitaires St Luc, Brussels, Belgium; Reuven Or, Hadassah University Hospital, Jerusalem, IsraelYves Chalandon, Hôpitaux Universitaires de Genève, Geneva, Switzerland; Carlos Solano, Hospital Clínico Universitario, Valencia, Spain; Keith Wilson, University Hospital of Wales, Cardiff, Wales, UK; Josep Maria Ribera Santasusana, ICO-Hospital Universitari Germans Trias i Pujol, Barcelona, Spain; Dimitrios Karakasis, Evangelismos Hospital, Athens, Greece; Kerstin Schäfer-Eckart, Klinikum Nürnberg, Nürnberg, Germany; Anders Wahlin, Umea University Hospital, Umeå, Sweden; Mohamad Mohty, Hospital Saint Antoine, Paris, France; Andrea Velardi, Ospedale Santa Maria della Misericordia, Perugia, Italy; Dominique Bron, Institut Jules Bordet, Brussels, Belgium; Adrián Alegre, Hospital de la Princesa, Madrid, Spain; Roberto Cairoli, Ospedale di Niguarda Ca' Granda, Milano, Italy; Giuseppe Marotta, Azienda Ospedaliera Universitaria Senese, Siena, Italy; Andrzej Lange, DCTK, Wroclaw, Poland; Franco Narni, Azienda Ospedaliero Universitaria di Modena Policlinico, Modena, Italy; Axel Fauser, Klinik für Knochenmarktransplantation, Idar-Oberstein, Germany; Alessandro Rambaldi, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy; Gaelle Guillerm, C.H.R.U de Brest, Brest, France; Inmaculada Heras, Hospital Morales Meseguer, Murcia, Spain; John Snowden, Royal Hallamshire Hospital, Sheffield, UK; Wieslaw Wiktor-Jedrzejczak, Central Clinical Hospital, Warsaw, Poland; Urs Schanz, University Hospital, Zürich, Switzerland; Jean Yves Cahn, Hopital A. Michallon, Grenoble, France; Manuel Abecasis, Inst. Portugues Oncologia, Lisboa, Portugal; Guido Kobbe, Heinrich Heine Universität, Düsseldorf, Germany; Rahuman Salim, Royal Liverpool University Hospital, Liverpool, UK; Christian Junghanss, Universität Rostock, Rostock, Germany; Erik Kay Segel, Arhus Amtssygehus, Aarhus, DenmarkL. Clement, Hopital d'Enfants, Vandoeuvre Les Nancy, France; Pavel Zák, Charles University Hospital, Hradec Králové, Czech Republic; Bernd Metzner, Klinikum Oldenburg, Oldenburg, Germany; Ildefonso Espigado, Hospital Universitario Virgen del Rocío, Sevilla, Spain; Herve Tilly, Centre Henri Becquerel, Rouen, France; Wilfried Schroyens, Antwerp University Hospital (UZA), Antwerp Edegem, Belgium; Claudio Favre, Azienda Ospedaliera Universitaria Pisa, Pisa, Italy; Domenico Russo, Azienda Ospedaliera Spedali Civili Di Brescia, Brescia, Italy; Günther Gastl, University Hospital Innsbruck, Innsbruck, Austria; Jacques-Olivier Bay, CHU ESTAING, Clermont-Ferrand, France; Emilio Paolo Alessandrino, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Ignazio Majolino, Ospedale S Camillo, Rome, Italy; Alberto Bosi, Ospedale di Careggi, Firenze, Italy; Tsila Zuckerman, Rambam Medical Center, Haifa, IsraelMahmoud Aljurf, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; Jackie Thomson, Haematology Pretoria East Hospital, Pretoria Gauteng, South Africa; Pietro Pioltelli, Ospedale San Gerardo, Monza, Italy; Achilles Anagnostopoulos, George Papanicolaou General Hospital, Thessaloniki, GreeceHarry Schouten, University Hospital Maastricht, Maastricht, The Netherlands; Eleni Tholouli, Manchester Royal Infirmary, Manchester, UK; Gunhan Gurman, Ankara University Faculty of Medicine, Ankara, Turkey; Filiz Vural, Ege University Medical School, Izmir, Turkey; Samo Zver, University Medical Center, Ljubljana, Slovenia; Soledad González Muñiz, Hospital Universitario Central de Asturias, Asturias, Spain; Boris Afanasyev, Saint Petersburg State Medical Pavlov University, St Petersburg, Russia; David Pohlreich, Charles University Hospital, Prague, Czech Republic; Andrzej Hellmann, Medical University of Gdansk, Gdansk, Poland; Wolf Rösler, University Hospital Erlangen, Erlangen, Germany; Sonja Martin, Robert-Bosch-Krankenhaus, Stuttgart, Germany; Jane Apperley, Hammersmith Hospital, London, UK; Damian Finnegan, Belfast City Hospital, Belfast, Northern Ireland, UK; Marc Renaud, Hopital Bretonneau, Tours, France; Damir Nemet, University Hospital Center Rebro, Zagreb, Croatia; Dominic Culligan, Aberdeen Royal Infirmary – Foresterhill, Aberdeen, UK; Luca Castagna, Istituto Clinico Humanitas, Rozzano Milano, Italy; Nicola Cascavilla, IRCCS, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; Mickey Koh, St George's Hospital, London, UK; Manuel Jurado Chacón, Hospital Universitario Virgen de las Nieves, Granada, Spain; Hakan Ozdogu, Baskent University Hospital, Yuregir Adana, Turkey; Andrew Spencer, The Alfred Hospital, Melbourne, Australia; Carlos Vallejo Llamas, Hospital Universitario Donostia, San Sebastian Gipuzkoa, Spain; Mariella Grasso, Az. Ospedaliera S Croce e Carle, Cuneo, Italy; Sebastian Garzon Lopez, Hospital del SAS, Cádiz Jerez de la Frontera, Spain; Fabio Benedetti, Policlinico GB Rossi, Verona, Italy; Dries Deeren, AZ Delta, Roeselare, Belgium; Thierry de Revel, Hôpital d'instruction des armées Percy, Clamart, France; Maurizio Musso, Ospedale La Maddalena - Dpt. Oncologico, Palermo, Italy; Kazimierz Halaburda, Institute of Hematology and Transfusion Medicine, Warsaw, Poland; Anna Sureda, ICO-Hospital Duran i Reynals, Barcelona, Spain; Emanuele Angelucci, Ospedale 'A Businco' Cagliari, Cagliari, Italy; José Luis Diez-Martin, Hospital Gregorio Marañón, Madrid, Spain; Hannah Hunter, Derriford Hospital, Plymouth, UK; Yener Koc, Medical Park Hospitals, Antalya, Turkey; Dominique Bordessoule, CHRU Limoges, Limoges, France; Loic Fouillard, Centre Hospitalier de Meaux, Meaux, France; Paolo Di Bartolomeo, Ospedale Civile, Pescara, Italy; Patrizio Mazza, Ospedale Nord, Taranto, Italy; Nicolas Novitzky, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa; Christian Peschel, Klinkum Rechts der Isar, Munich, Germany; Jose Luis Bello López, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago De Compostela, Spain; Maria Jesús Pascual Cascon, Hospital Regional de Málaga, Málaga, Spain; Kenneth R. Romeril, Wellington Hospital, Wellington, New ZealandRik Schots, Universitair Zieken; huis Brussel, Brussels, Belgium; Pirjo Koistinen, Oulu University Hospital, Oulu, Finland; William Arcese, Policlinico Universitario Tor Vergata, Rome, Italy; Melih Aktan, Ýstanbul Tip Fakultesi, Istanbul, Turkey; Francesco Rodeghiero, S Bortolo Hospital, Vicenza, Italy; Andrew Butler, Canterbury Health Laboratories, Christchurch, New Zealand; Michele Pizzuti, Ospedale San Carlo, Potenza, Italy; Anglea Melpignano, Perrino Hospital, Brindisi, Italy; Angelo Michele Carella, Azienda Ospedaliera Universitaria San Martino, Genova, Italy; David Valcárcel/José Sánchez de Toledo Codina, Hospital Vall d'Hebron, Barcelona, Spain; Piero Galieni, Mazzoni Hospital, Ascoli Piceno, Italy; Peter Bader, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany; Dr Hahn, Buergerhospital, Stuttgart, GermanyLuigi Cavanna, Hospital Guglielmo da Saliceto, Piacenza, Italy; Gülsan Sucak, Gazi Universitesi Tip Fakültesi Hastanesi, Ankara, Turkey; Angus JM Broom, Western General Hospital, Edinburgh, UK; Pedro Gomez García, Hospital Reina Sofia, Córdoba, Spain; Emmanuelle Nicolas-Virelizier, Centre Leon Berard, Lyon, France; Vittorio Rizzoli, University of Parma, Parma, ItalyF Witz, CHU Nancy-Brabois, Nancy, France; Mike Potter, The Trustee of London Clinic, London, UK; Matthew Collin, Freeman Hospital, Newcastle Upon Tyne, UK; Mark Ringhoffer, Klinikum Karlsruhe gGmbH, Karlsruhe, Germany; Emin Kansu, Hacettepe University, Ankara, Turkey; Hans Martin, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany; José Moraleda, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; Delphine Pranger, GHDC, Charleroi, Belgium; Richard Greil, Landeskliniken Betriebsges.mbH, Salzburg, Austria; Ali Bazarbachi, American University of Beirut Medical Center, Beirut, Lebanon; Mustafa Ozturk, Gülhane Military Medical Academy, Ankara Etlik, Turkey; Franca Fagioli, Ospedale Infantile Regina Margherita, Torino, Italy; Esa Jantunen, Kuopio University Hospital, Kuopio, Finland; Moshe Yeshurun, Beilinson Hospital, Petach-Tikva, Israel; Fevzi Altuntas, Ankara Oncology Research and Education Hospital, Ankara, Turkey; Renato Bassan, Ospedale Dell'Angelo, Venezia-Mestre, Italy; Pierre-Simon Rohrlich, CHU Nice — Hôpital de l'ARCHET I, Nice, France; Santiago Jimenez, Hospital de Gran Canaria 'Dr Negrin', Las Palmas, De Gran Canaria, Spain; Sylvie Glaisner, Centre Rene Huguenin, Saint-Cloud, France; Orazio Vinante, Civic Hospital, Noale, Italy; Johannes Clausen, Elisabethinen-Hospital, Linz, Austria; Javier López-Jiménez, Hospital Ramón y Cajal, Madrid, Spain; Koen Theunissen, Jessa Ziekenhuis, Hasselt, Belgium; Giorgina Specchia, Azienda Ospedaliero Universitaria Policlinico Bari, Bari, Italy; Vincenzo Pavone, Hospital C Panico, Tricase, Lecce, Italy; Jürgen Krauter, Städtisches Klinikum Braunschweig, Braunschweig, Germany; David Edwards, Ysbyty Gwynedd, Bangor, Wales, UK; Jose Rifón, Clínica Universitaria de Navarra, Pamplona, Spain; Hele Everaus, Tartu University Hospital, Tartu, Estonia; Gian Antonia Da Prada, Fondazione S Maugeri, Pavia, Italy; Mohammed Wattad, Kliniken Essen Süd, Essen, Germany; Giuseppe Milone, Ospedale Ferrarotto, Catania, Italy; Jan Walewski, The Maria Sklodowska-Curie Memorial Cancer Centre, Warsaw, Poland; Catherine Thieblemont, Hôpital St Louis, Paris, France; Giorgio La Nasa, Centro Trapianti di Midollo Osseo, Cagliari, ItalyMichel Duchosal, Universitaire Vaudois, Lausanne, Switzerland; Felicetto Ferrara, Cardarelli Hospital, Napoli, Italy; Alain Devidas, Centre Hospitalier Gilles de Corbeil, Corbeil-Essone, France; Alain Delmer, Hôpital Robert Debre, Reims, France; Laurent Degos, St Louis, Paris, France

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van Gelder, M., de Wreede, L., Bornhäuser, M. et al. Long-term survival of patients with CLL after allogeneic transplantation: a report from the European Society for Blood and Marrow Transplantation. Bone Marrow Transplant 52, 372–380 (2017). https://doi.org/10.1038/bmt.2016.282

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