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ABO incompatibility does not influence transfusion requirements in patients undergoing single-unit umbilical cord blood transplantation

Bone Marrow Transplantation volume 52, pages 394–399 (2017)Cite this article

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Abstract

Hematopoietic stem cell transplantation is usually performed without considering the ABO compatibility between donor and recipient. There are few studies analyzing ABO matching impact on transfusion outcome of umbilical cord blood transplantation (UCBT) recipients. The aim of this study was to analyze factors influencing transfusion outcome, highlighting the ABO matching between donor and recipient. This study has reviewed data from 318 patients who underwent single unit UCBT at la Fe University Hospital from January 2000 to December 2014. There were no differences between RBC and platelet (PLT) requirements or RBC and PLT transfusion independence according to ABO matching between donor and recipient. RBC and PLT requirements were statistically correlated (ρ=0,841, P<0.001). A total of 170 and 188 patients achieved RBC and PLT independence, respectively, within 180 days after UCBT. Persistence of recipient isoagglutinins was detected in 6.8% of patients with major ABO incompatibility at median of 176 days (103–269) after UCBT. Autoimmune haemolytic anemia was diagnosed in 15 patients, 12 of them due to cold antibodies. In conclusion, ABO matching has not influenced transfusion requirements of patients undergoing UCBT.

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Acknowledgements

We thank to Mr P Gutteridge for his assistance in the revision of the manuscript.

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Authors and Affiliations

  1. Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain

    P Solves, N Carpio, C Carretero, J I Lorenzo, J Sanz, I Gómez, F López-Chuliá, M J Arilla, A I Regadera, P Montesinos, G F Sanz & M Á Sanz

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  1. P Solves
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  2. N Carpio
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  3. C Carretero
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  4. J I Lorenzo
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  7. F López-Chuliá
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  10. P Montesinos
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Correspondence to P Solves.

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Solves, P., Carpio, N., Carretero, C. et al. ABO incompatibility does not influence transfusion requirements in patients undergoing single-unit umbilical cord blood transplantation. Bone Marrow Transplant 52, 394–399 (2017). https://doi.org/10.1038/bmt.2016.264

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