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Comparable outcomes following two or three cycles of high-dose chemotherapy and autologous stem cell transplantation for patients with relapsed/refractory germ cell tumors

Bone Marrow Transplantation volume 52, pages 132–134 (2017)Cite this article

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Germ cell tumors are among the most curable of solid tumors, with long-term durable remissions seen in >80% of good-risk patients and 50–60% of poor-risk patients.1 However, in 20–30% of patients, the tumor persists or recurs after initial treatment and salvage therapies are required. High-dose chemotherapy (HDC) followed by autologous hematopoietic stem cell transplantation (HDC–HSCT) is a potentially curative approach for this previously treated population, with reported long-term post-transplant survival as high as 70%.2 Questions remain regarding the optimal regimen of HDC and the timing of its use. We reviewed our institutional experience with two different sequential HDC regimens for previously treated germ cell tumors to evaluate and compare the outcomes with this salvage approach.

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Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA

    Z DeFilipp, C B Rosand, D A Goldstein, B C Carthon, W B Harris, O Kucuk, Z Al-Kadhimi, J B Cohen, C R Flowers, M J Lechowicz, A K Nooka, J L Kaufman, A A Langston & E K Waller

  2. Department of Urology, Emory University School of Medicine, Atlanta, GA, USA

    V A Master

  3. Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, USA

    Z Chen & J Arora

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  1. Z DeFilipp
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Correspondence to E K Waller.

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DeFilipp, Z., Rosand, C., Goldstein, D. et al. Comparable outcomes following two or three cycles of high-dose chemotherapy and autologous stem cell transplantation for patients with relapsed/refractory germ cell tumors. Bone Marrow Transplant 52, 132–134 (2017). https://doi.org/10.1038/bmt.2016.189

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