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Prognostic significance of liver parameters at 1-year follow-up in children and adults undergoing myeloablative allogeneic stem cell transplantation

Bone Marrow Transplantation volume 50, pages 876–877 (2015)Cite this article

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Liver involvement during the early toxicity phase after hematopoietic stem cell transplantation (HSCT) is well documented, with reports of mild to moderate elevation in liver enzymes and bilirubin in up to 80% of the patients.1, 2, 3 In contrast, our knowledge regarding liver impairment at long-term follow-up is limited. The primary aim of this study was to describe liver parameters at 1-year follow-up after HSCT and to identify risk factors. The secondary aim was to analyze the impact of liver affection at 1-year follow-up on long-term survival beyond 1 year.

We retrospectively studied alanine aminotransferase (ALT) and bilirubin levels at 1-year follow-up in patients undergoing HSCT at the National Danish HSCT center between 1998 and 2008. Inclusion criteria were (1) first myeloablative allogeneic HSCT, (2) transplantation with either matched sibling donors or matched unrelated donors and (3) available ALT and bilirubin data at 1-year follow-up. Out of 356 patients who were eligible for the study, 219 patients (126 males and 93 females, Table 1) met these criteria and were included in the study; of those 26% were children <16 years of age. The mean of ALT and bilirubin values available between days 330 and 390 post HSCT was used for statistical analysis.

Table 1 Baseline characteristics of 219 patients transplanted in the period of 1998–2008 and surviving at 1 year post HSCT
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Acknowledgements

This work has been supported by grants from The Danish Cancer Society, Dagmar Marshall Fond,Tømrermester Holm og Hustru Elisa f. Hansens Mindelegat and Juliane Marie Centeret, Rigshospitalet.

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Authors and Affiliations

  1. Department of Paediatric and Adolescent Medicine 4072, National University Hospital, Rigshospitalet, Copenhagen, Denmark

    K Jordan, M H Jørgensen, C Heilmann & K G Müller

  2. Institute for Inflammation Research 7841, National University Hospital, Rigshospitalet, Copenhagen, Denmark

    K Jordan & K G Müller

  3. The Finsen Laboratory, Rigshospitalet and Biotech Research and, Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark

    I J Christensen

  4. Department of Haematology 4042, National University Hospital, Rigshospitalet, Copenhagen, Denmark

    H Sengeløv

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  1. K Jordan
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Correspondence to K Jordan.

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Jordan, K., Christensen, I., Jørgensen, M. et al. Prognostic significance of liver parameters at 1-year follow-up in children and adults undergoing myeloablative allogeneic stem cell transplantation. Bone Marrow Transplant 50, 876–877 (2015). https://doi.org/10.1038/bmt.2015.54

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