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Pre-transplant sirolimus might improve the outcome of haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide for patients with severe aplastic anemia

Bone Marrow Transplantation volume 50, pages 873–875 (2015)Cite this article

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Severe aplastic anemia (SAA) in developing countries may be treated with hematopoietic cell transplantation (HCT) from a matched family donor, but a sequential approach with immunosuppression first and an alternative donor HCT after failure, is rarely possible due to resource constraints.

In a pilot study we explored the feasibility of post-transplant cyclophosphamide (PTCY)-based haploidentical HCT in 10 patients (median 35 years, 6–46 years) with SAA without matched family donors. Written informed consent and ethical approval were obtained from all patients in accordance with the Declaration of Helsinki Principles. The conditioning protocol consisted of Fludarabine 30 mg/m2/day for 5 days and Cyclophosphamide 15 mg/kg/day for 2 days with Melphalan 120 mg/m2 replacing 2 Gy total body irradiation (TBI;1 due to lack of TBI facilities and the success of this protocol in our malignant cohort) along with horse antithymocyte globulin (ATG), at 15 mg/kg for 3 days from day −8 to day −6.

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Authors and Affiliations

  1. Department of Blood and Marrow Transplantation, Dharamshila Hospital and Research Centre, New Delhi, India

    S R Jaiswal & S Chakrabarti

  2. Manashi Chakrabarti Foundation, Kolkata, India

    S R Jaiswal, S Chatterjee & S Chakrabarti

  3. Apollo Gleneagles Hospital, Kolkata, India

    S Chatterjee

  4. CSIR-Indian Institute of Chemical Biology, Kolkata, India

    S Mukherjee & K Ray

  5. Academy of Scientific and Innovative Research, CSIR-CRRI, New Delhi, India

    K Ray

Authors
  1. S R Jaiswal
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  2. S Chatterjee
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  3. S Mukherjee
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  4. K Ray
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  5. S Chakrabarti
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Correspondence to S Chakrabarti.

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Jaiswal, S., Chatterjee, S., Mukherjee, S. et al. Pre-transplant sirolimus might improve the outcome of haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide for patients with severe aplastic anemia. Bone Marrow Transplant 50, 873–875 (2015). https://doi.org/10.1038/bmt.2015.50

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