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Impact of a lifestyle modification program on the metabolic syndrome and associated risk factors in long-term survivors of stem cell transplantation

Bone Marrow Transplantation volume 51, pages 722–724 (2016)Cite this article

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Cardiovascular disease is a major cause of late morbidity and increased mortality in long-term survivors of haematological malignancy treated with stem cell transplantation (SCT).1, 2 The metabolic syndrome (MetS), a clustering of risk factors for cardiovascular disease, occurs frequently after SCT.3, 4 Lifestyle intervention is effective in reducing the occurrence of MetS and its components in both general population cohorts5 and survivors of non-haematological cancers,6 however, effectiveness following SCT is not established. This prospective pilot study aimed to assess the effectiveness of a 12-month lifestyle intervention program on reducing the number and/or severity of MetS risk factors in long-term survivors of SCT.

Recruitment of consecutive participants occurred from an established post-SCT long-term follow-up clinic at the Alfred Hospital, Melbourne, Australia between July 2012 and July 2013. The study population consisted of recipients of either autologous or allogeneic SCT performed for the management of haematological malignancy. Participants were ⩾18 years of age and at least 2 years post-transplantation. Patients with relapsed disease, an absolute neutrophil count <1.0 × 109/L, ongoing significant immunosuppression or symptomatic anaemia were excluded. Ethics approval was granted by The Alfred Hospital Ethics committee in accordance with the National Statement on Ethical Conduct in Human Research (2007).

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References

  1. Chow EJ, Mueller BA, Baker KS, Cushing-Haugen KL, Flowers ME, Martin PJ et al. Cardiovascular hospitalizations and mortality among recipients of hematopoietic stem cell transplantation. Ann Intern Med 2011; 155: 21–32.

    Article  Google Scholar 

  2. Armenian SH, Sun CL, Vase T, Ness KK, Blum E, Francisco L et al. Cardiovascular risk factors in hematopoietic cell transplantation survivors: role in development of subsequent cardiovascular disease. Blood 2012; 120: 4505–4512.

    Article  CAS  Google Scholar 

  3. Annaloro C, Usardi P, Airaghi L, Giunta V, Forti S, Orsatti A et al. Prevalence of metabolic syndrome in long-term survivors of hematopoietic stem cell transplantation. Bone Marrow Transplant 2008; 41: 797–804.

    Article  CAS  Google Scholar 

  4. Majhail NS, Flowers ME, Ness KK, Jagasia M, Carpenter PA, Arora M et al. High prevalence of metabolic syndrome after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 2009; 43: 49–54.

    Article  CAS  Google Scholar 

  5. Bassi N, Karagodin I, Wang S, Vassallo P, Priyanath A, Massaro E et al. Lifestyle modification for metabolic syndrome: a systematic review. Am J Med 2014; 127: e1–e10.

    Article  Google Scholar 

  6. Demark-Wahnefried W, Jones LW . Promoting a healthy lifestyle among cancer survivors. Hematol Oncol Clin North Am 2008; 22: 319–342.

    Article  Google Scholar 

  7. Vale MJ, Jelinek MV, Best JD, Dart AM, Grigg LE, Hare DL et al. Coaching patients On Achieving Cardiovascular Health (COACH): a multicenter randomized trial in patients with coronary heart disease. Arch Intern Med 2003; 163: 2775–2783.

    Article  Google Scholar 

  8. Jelinek M, Vale MJ, Liew D, Grigg L, Dart A, Hare DL et al. The COACH program produces sustained improvements in cardiovascular risk factors and adherence to recommended medications-two years follow-up. Heart Lung Circ 2009; 18: 388–392.

    Article  Google Scholar 

  9. World Health Organization Physical status: the use and interpretation of anthropometry. World Health Organization: Geneva, 1995.

  10. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA et alHarmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity Circulation 2009; 120: 1640–1645.

    Article  CAS  Google Scholar 

  11. Cameron AJ, Magliano DJ, Zimmet PZ, Welborn T, Shaw JE . The metabolic syndrome in Australia: prevalence using four definitions. Diabetes Res Clin Pract 2007; 77: 471–478.

    Article  Google Scholar 

  12. Natarajan P, Ray KK, Cannon CP . High-density lipoprotein and coronary heart disease: current and future therapies. J Am Coll Cardiol 2010; 55: 1283–1299.

    Article  CAS  Google Scholar 

  13. Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD et al. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation 1989; 79: 8–15.

    Article  CAS  Google Scholar 

  14. Rubins HB, Robins SJ, Collins D, Fye CL, Anderson JW, Elam MB et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med 1999; 341: 410–418.

    Article  CAS  Google Scholar 

  15. Wing RR, Lang W, Wadden TA, Safford M, Knowler WC, Bertoni AG et al. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care 2011; 34: 1481–1486.

    Article  CAS  Google Scholar 

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Acknowledgements

We acknowledge the participants of the study as well as the staff of the Late Effects Clinic at The Alfred Hospital, particularly Helen McLauchlan. This project was supported by the Victorian Government.

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Authors and Affiliations

  1. Department of Nutrition and Dietetics, Alfred Health, Commercial Road, Melbourne, Victoria, Australia

    E Viner Smith & A C Tierney

  2. Department of Dietetics and Human Nutrition, La Trobe University, Melbourne, Victoria, Australia

    A C Tierney

  3. Malignant Haematology and Stem Cell Transplantation Service, Alfred Health, Commercial Road, Melbourne, Victoria, Australia

    D Klarica, P Walker & S Avery

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  1. E Viner Smith
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  2. A C Tierney
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  3. D Klarica
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Correspondence to S Avery.

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Viner Smith, E., Tierney, A., Klarica, D. et al. Impact of a lifestyle modification program on the metabolic syndrome and associated risk factors in long-term survivors of stem cell transplantation. Bone Marrow Transplant 51, 722–724 (2016). https://doi.org/10.1038/bmt.2015.312

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