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Does ex vi vo CD34+ positive selection influence outcome after autologous hematopoietic stem cell transplantation in systemic sclerosis patients?

Bone Marrow Transplantation volume 51, pages 501–505 (2016)Cite this article

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An Erratum to this article was published on 01 June 2016

Abstract

This EBMT Autoimmune Disease Working Party study aimed to evaluate the influence of CD34+ positive graft selection (CD34+) on the outcome of systemic sclerosis (SSc) patients after autologous hematopoietic stem cell transplantation (AHSCT). Clinical and laboratory data from 138 SSc patients at diagnosis, before and after AHSCT were retrospectively analyzed. CD34+ selection was performed in 47.1% (n=65) patients. By multivariate analysis adjusting for all factors differing between the two groups (without or with CD34+), there was no statistically significant difference in terms of overall survival (hazard ratio (HR): 0.98, 95% confidence interval (CI) 0.40–2.39, P=0.96), PFS (HR: 1.55, 95% CI 0.83–2.88, P=0.17) and incidence of relapse or progression (HR: 1.70, 95% CI 0.85–3.38, P=0.13). We demonstrate that CD34+ does not add benefit to the outcome of SSc patient treated with AHSCT. These findings should be further confirmed by prospective randomized trials.

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Author information

Authors and Affiliations

  1. Division of Clinical Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

    M C Oliveira

  2. EBMT, Hôpital Saint Antoine, Paris, France

    M Labopin

  3. Medizinische Universitätsklinik Abt. II, Tübingen, Germany

    J Henes

  4. Department of Haematology, St Vincent’s Hospital, Sydney, New South Wales, Australia

    J Moore

  5. Scleroderma Clinic, U.O.C. Day Hospital Rheumatology, Osp. G. Pini, Milan, Italy

    N D Papa

  6. Assistance Publique-Hôpitaux de Paris, Saint-Louis Hospital, Cell Therapy Unit, Cord Blood Bank and CIC-BT501, Paris, France

    A Cras

  7. INSERM UMRS 1140, Paris Descartes, Faculté de Pharmacie, Paris, France

    A Cras

  8. Bone Marrow Transplantation Unit, George Papanicolaou General Hospital, Thessaloniki, Greece

    I Sakellari

  9. Ruhr-Universität Bochum, Medizinische Klinik Knappschaftskrankenhaus, Bochum, Germany

    R Schroers

  10. Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands

    H U Scherer

  11. University of Ferrara—St Anna Hospital, Ferrara, Italy

    A Cuneo

  12. Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Katowice, Poland

    S Kyrcz-Krzemien

  13. Department of Rheumatology, University Hospital Basel, Basel, Switzerland

    T Daikeler

  14. Department of Rheumatology and Clinical Immunology, Charité—University Medicine Berlin, Berlin, Germany

    T Alexander

  15. Department of Medicine—Hematology and Oncology, University of Freiburg, Freiburg

    J Finke

  16. Germany,

    J Finke

  17. EBMT Paris Office, Hôpital Saint Antoine, Paris, France

    M Badoglio

  18. Division of Hematology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

    B Simões

  19. Department of Hematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

    J A Snowden

  20. Paris 7 University, INSERM U1160, Paris, France

    D Farge

  21. Unité de Médecine Interne et Pathologie Vasculaire, Saint Louis Hospital, Assistance Publique des Hôpitaux de Paris, Paris 7 Denis Diderot University, Paris, France

    D Farge

Authors
  1. M C Oliveira
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  2. M Labopin
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  3. J Henes
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  4. J Moore
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  5. N D Papa
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  6. A Cras
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  13. T Alexander
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  14. J Finke
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  15. M Badoglio
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  16. B Simões
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  17. J A Snowden
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  18. D Farge
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for the EBMT Autoimmune Diseases Working Party

Corresponding authors

Correspondence to M C Oliveira or D Farge.

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The authors declare no conflict of interest.

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Author contributions

DF, JS, MCO and ML conceived the study. DF, MCO, JH, JM, NDP, RS, IS, RS, HUS, SKK, TD, TA, JF, BS and JS planned the study and provided data; MB collected and managed the data; ML analyzed the data; MCO, DF and ML wrote the manuscript; DF and JS critically revised the manuscript.

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Oliveira, M., Labopin, M., Henes, J. et al. Does ex vi vo CD34+ positive selection influence outcome after autologous hematopoietic stem cell transplantation in systemic sclerosis patients?. Bone Marrow Transplant 51, 501–505 (2016). https://doi.org/10.1038/bmt.2015.299

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