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Lymphoma

Early application of related SCT might improve clinical outcome in adult T-cell leukemia/lymphoma

Bone Marrow Transplantation volume 51, pages 205–211 (2016)Cite this article

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Abstract

Allogeneic hematopoietic SCT (allo-HSCT) is a curative treatment for aggressive adult T-cell leukemia/lymphoma (ATLL). Considering the dismal prognosis associated with conventional chemotherapies, early application of allo-HSCT might be beneficial for patients with ATLL. However, no previous study has addressed the optimal timing of allo-HSCT from related donors. Hence, to evaluate the impact of timing of allo-HSCT for patients with ATLL, we retrospectively analyzed data from patients with ATLL who received an allo-HSCT from a related donor. The median age was 52 years. Patients were grouped according to the interval from diagnosis to allo-HSCT: early transplant group, <100 days, n=72; late transplant group, ⩾100 days, n=428. The corresponding constituents of disease status were not statistically different between the two groups (P=0.11). The probability of OS in the early transplant group was significantly higher than that in the late transplant group (4-year OS, 49.3% vs 31.2%). Multivariate analysis revealed that late allo-HSCT was an unfavorable prognostic factor for OS (hazard ratio, 1.46; 95% confidence interval (CI), 1.01–2.11; P=0.04). Despite the limitations of a retrospective study, it might be acceptable to consider early application of allo-HSCT for ATLL.

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Acknowledgements

This work was supported by grants from the Japanese Ministry of Health, Labour and Welfare. We thank the medical, nursing, data-processing, laboratory and clinical staff at the participating centers for their important contributions to this study and their dedicated care of the patients.

Author contributions

SF participated in research design, data analysis and writing of the paper; HF participated in research design, data analysis and writing of the paper; NN, AW and YI participated in research design; TF, MH, YM, TI and YA gathered the data; AU participated in research design and writing of the paper. All authors approved the submission of this study.

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Authors and Affiliations

  1. Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan

    S Fuji, Y Inoue & T Fukuda

  2. First Department of Internal Medicine, Ehime University Hospital, Ehime, Japan

    H Fujiwara

  3. Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan

    N Nakano & A Utsunomiya

  4. Department of Hematology, Toranomon Hospital Kajigaya, Kanagawa, Japan

    A Wake

  5. Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan

    M Hidaka

  6. Department of Hematology, Sasebo City General Hospital, Nagasaki, Japan

    Y Moriuchi

  7. Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka, Japan

    T Miyamoto

  8. Department of Hematology, National Kyushu Cancer Center, Fukuoka, Japan

    N Uike

  9. Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Nagasaki University Hospital, Nagasaki, Japan

    J Taguchi

  10. Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan

    T Eto

  11. Second Department of Internal Medicine, Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, University Hospital, University of the Ryukyus, Okinawa, Japan

    T Tomoyose

  12. Department of Hematology/Oncology, Kyoto University Hospital, Kyoto, Japan

    T Kondo

  13. Department of Haematology, Heart-Life Hospital, Okinawa, Japan

    A Yamanoha

  14. Department of Hematology and Oncology, Hiroshima University Hospital, Hiroshima, Japan

    T Ichinohe

  15. Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan

    Y Atsuta

  16. Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Y Atsuta

Authors
  1. S Fuji
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  2. H Fujiwara
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  3. N Nakano
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  4. A Wake
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  5. Y Inoue
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  6. T Fukuda
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  7. M Hidaka
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  8. Y Moriuchi
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  9. T Miyamoto
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  10. N Uike
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  11. J Taguchi
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  12. T Eto
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  13. T Tomoyose
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  14. T Kondo
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  15. A Yamanoha
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  16. T Ichinohe
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  17. Y Atsuta
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  18. A Utsunomiya
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ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation

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Correspondence to S Fuji.

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The authors declare no conflict of interest.

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Fuji, S., Fujiwara, H., Nakano, N. et al. Early application of related SCT might improve clinical outcome in adult T-cell leukemia/lymphoma. Bone Marrow Transplant 51, 205–211 (2016). https://doi.org/10.1038/bmt.2015.265

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  • DOI: https://doi.org/10.1038/bmt.2015.265

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