Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Urinary-derived human chorionic gonadotropin to induce tolerance and promote healing in steroid-refractory GvHD

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Elmaagacli AH, Ditschkowski M, Steckel NK, Gromke T, Ottinger H, Hillen U et al. Human chorionic gonadotropin and indolamine 2,3-dioxygenase in patients with GVHD. Bone Marrow Transplant 2014; 49: 800–805.

    Article  CAS  Google Scholar 

  2. Schumacher A, Heinze K, Witte J, Poloski E, Linzke N, Woidacki K et al. Human chorionic gonadotropin as a central regulator of pregnancy immune tolerance. J Immunol 2013; 190: 2650–2658.

    Article  CAS  Google Scholar 

  3. Yarram SJ, Jenkins J, Cole LA, Brown NL, Sandy JR, Mansell JP . Epidermal growth factor contamination and concentrations of intact human chorionic gonadotropin in commercial preparations. Fertil Steril 2004; 82: 232–233.

    Article  CAS  Google Scholar 

  4. Holtan SG, Verneris MR, Schultz KR, Newell LF, Meyers G, He F et al. Circulating angiogenic factors associated with response and survival in patients with acute graft-versus-host disease: results from Blood and Marrow Transplant Clinical Trials Network 0302 and 0802. Biol Blood Marrow Transplant 2015; 21: 1029–1036.

    Article  CAS  Google Scholar 

  5. Holtan SG, Chen Y, Kaimal R, Creedon DJ, Enninga EA, Nevala WK et al. Growth modeling of the maternal cytokine milieu throughout normal pregnancy: macrophage-derived chemokine decreases as inflammation/counterregulation increases. J Immunol Res 2015; 2015: 952571.

    Article  Google Scholar 

Download references


This work was supported in part by the UMN Cytokine Reference Laboratory (AP-M), and the Masonic Cancer Center, University of Minnesota (SGH). We thank Michael Ehrhardt for expert technical assistance.

Author information

Authors and Affiliations


Corresponding author

Correspondence to S G Holtan.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Holtan, S., Panoskaltsis-Mortari, A. Urinary-derived human chorionic gonadotropin to induce tolerance and promote healing in steroid-refractory GvHD. Bone Marrow Transplant 51, 142–143 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links