Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Host immunity dictates influenza A(H1N1)pdm09 infection outcome in hematology–oncology patients

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1
Figure 2

References

  1. Redelman-Sidi G, Sepkowitz KA, Huang CK, Park S, Stiles J, Eagan J et al. 2009 H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients. J Infect 2010; 60: 257–263.

    Article  Google Scholar 

  2. Nichols WG, Guthrie KA, Corey L, Boeckh M . Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy. Clin Infect Dis 2004; 39: 1300–1306.

    Article  Google Scholar 

  3. Gooskens J, Jonges M, Claas EC, Meijer A, Kroes AC . Prolonged influenza virus infection during lymphocytopenia and frequent detection of drug-resistant viruses. J Infect Dis 2009; 199: 1435–1441.

    CAS  Article  Google Scholar 

  4. Tramontana AR, George B, Hurt AC, Doyle JS, Langan K, Reid AB et al. Oseltamivir resistance in adult oncology and hematology patients infected with pandemic (H1N1) 2009 virus, Australia. Emerg Infect Dis 2010; 16: 1068–1075.

    CAS  Article  Google Scholar 

  5. Ljungman P, de la Camara R, Perez-Bercoff L, Abecasis M, Nieto Campuzano JB, Cannata-Ortiz MJ et al. Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients. Haematologica 2011; 96: 1231–1235.

    Article  Google Scholar 

  6. Choi SM, Boudreault AA, Xie H, Englund JA, Corey L, Boeckh M . Differences in clinical outcomes after 2009 influenza A/H1N1 and seasonal influenza among hematopoietic cell transplant recipients. Blood 2011; 117: 5050–5056.

    CAS  Article  Google Scholar 

  7. Hillaire M, Rimmelzwaan G, Kreijtz J . Clearance of influenza virus infections by T cells: risk of collateral damage? Curr Opin Virol 2013; 3: 430–437.

    CAS  Article  Google Scholar 

  8. van der Vries E, Jonges M, Herfst S, Maaskant J, Van der Linden A, Guldemeester J et al. Evaluation of a rapid molecular algorithm for detection of pandemic influenza A(H1N1) 2009 virus and screening for a key oseltamivir resistance (H275Y) substitution in neuraminidase. J Clin Virol 2010; 47: 34–37.

    CAS  Article  Google Scholar 

  9. Bodewes R, Fraaij PL, Geelhoed-Mieras MM, van Baalen CA, Tiddens HA, van Rossum AM et al. Annual vaccination against influenza virus hampers development of virus-specific CD8+ T cell immunity in children. J Virol 2011; 85: 11995–12000.

    CAS  Article  Google Scholar 

  10. Hakki M, Riddell SR, Storek J, Carter RA, Stevens-Ayers T, Sudour P et al. Immune reconstitution to cytomegalovirus after allogeneic hematopoietic stem cell transplantation: impact of host factors, drug therapy, and subclinical reactivation. Blood 2003; 102: 3060–3067.

    CAS  Article  Google Scholar 

  11. Hillaire ML, van Trierum SE, Bodewes R, van Baalen CA, van Binnendijk RS, Koopmans MP et al. Characterization of the human CD8+ T cell response following infection with 2009 pandemic influenza H1N1 virus. J Virol 2011; 85: 12057–12061.

    CAS  Article  Google Scholar 

  12. Thomas PG, Keating R, Hulse-Post DJ, Doherty PC . Cell-mediated protection in influenza infection. Emerg Infect Dis 2006; 12: 48–54.

    CAS  Article  Google Scholar 

  13. Jegaskanda S, Weinfurter JT, Friedrich TC, Kent SJ . Antibody-dependent cellular cytotoxicity is associated with control of pandemic H1N1 influenza virus infection of macaques. J Virol 2013; 87: 5512–5522.

    CAS  Article  Google Scholar 

  14. Narasaraju T, Yang E, Samy RP, Ng HH, Poh WP, Liew AA et al. Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis. Am J Pathol 2011; 179: 199–210.

    CAS  Article  Google Scholar 

  15. Fraaij PL, van der Vries E, Beersma MF, Riezebos-Brilman A, Niesters HG, van der Eijk AA et al. Evaluation of the antiviral response to zanamivir administered intravenously for treatment of critically ill patients with pandemic influenza A (H1N1) infection. J Infect Dis 2011; 204: 777–782.

    CAS  Article  Google Scholar 

Download references

Acknowledgements

We thank Eric Claas (Department of Medical Microbiology) and Geeske Brouwer-Mandema (Department of Hematology) for valuable assistance and advice. We are indebted to Martina Geelhoed-Mieras, Carel van Baalen and Tamara Roelofse (Department of Viroscience) for excellent technical support. None of these persons were financially compensated for providing assistance and technical support.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J Gooskens.

Ethics declarations

Competing interests

GFR reported his part-time employment as a consultant of Viroclinics Biosciences BV. The remaining authors declare no conflict of interest.

Additional information

International meeting at which all or part of the information has been presented: 17th International Symposium on Infections in the Immunocompromised Host, Genova, Italy, June 2012. 23rd European Congress of Clinical Microbiology and Infectious Diseases, Berlin, Germany, April 2013. 55th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, USA, September 2015.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Gooskens, J., Marijt, W., van Essen, E. et al. Host immunity dictates influenza A(H1N1)pdm09 infection outcome in hematology–oncology patients. Bone Marrow Transplant 51, 138–141 (2016). https://doi.org/10.1038/bmt.2015.214

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2015.214

Search

Quick links