OS according to each grade of aGvHD with or without hepatic aGvHD. OS was calculated with the Kaplan–Meier method after the landmark of 60 days from HCT according to the grade of aGvHD and the existence of hepatic aGvHD. The complication of hepatic aGvHD was the independent factor worsening OS at each grade of aGvHD. OS at 3 years was lower in patients with grade II aGvHD with hepatic lesions (44.1%; 95% CI, 32.4–52.3%) than those with grade II aGvHD without hepatic lesions (60.3%; 95% CI, 57.8–62.8%). Prognosis of grade III aGvHD without hepatic aGvHD (3-year OS, 45.2%; 95% CI, 39.7–50.6%) was much better than that of grade III aGvHD with hepatic aGvHD (3-year OS, 29.3%; 95% CI, 22.5–36.3%). Complication with grade IV aGvHD including hepatic lesions showed by far the worst survival (3-year OS, 5.9%; 95 % CI, 2.5–11.5%). Existence of hepatic aGvHD can be a strong prognostic factor in each grade of aGvHD (grade II–IV).